ReviewThe Plant cell2026
A cellular view of seed development and germination.
Review in The Plant cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seeds are fundamental to global food security, yet their encapsulated structure, dense storage compounds, and spatial heterogeneity have created a "hidden box" problem, often restricting research to bulk and tissue approaches that mask cell type-specific regulatory programs. Advances in single-cell and spatial transcriptomics now enable systematic dissection of seed biology at cellular resolution. This review provides a cellular view spanning the developmental continuum from fertilization to seedling establishment by synthesizing single-cell and spatial transcriptomic studies in Arabidopsis thaliana and major crops (Oryza sativa-rice, Zea mays-maize, Hordeum vulgare-barley, Glycine max-soybean, Triticum aestivum-wheat). These technologies reveal previously undetected cellular complexity and heterogeneity: distinct transcriptional subpopulations within morphologically uniform tissues, specialized endosperm microdomains mediating nutrient transfer and metabolic polarity, cell type-specific genomic imprinting patterns, and spatially segregated hormone signaling hubs controlling dormancy and germination. Integration of transcriptional profiling with chromatin accessibility and transcription factor binding data has enabled construction of cell type-specific gene regulatory networks for seeds, advancing from correlation to causal inference and identifying master regulators of developmental transitions. These approaches illuminate how early embryonic patterning establishes transcriptional identities, how metabolic zonation coordinates storage compound accumulation and mobilization, how chromatin states maintain dormancy and license germination competence, and how spatiotemporal coordination integrates hormone signaling with energy metabolism across tissues. Single-cell and spatial approaches are establishing seeds not as opaque structures but as assemblies of coordinated cellular programs amenable to systematic analysis and targeted manipulation for crop improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.