Evidence map›Paper›PMID 42886426›Full record

ArticleMolecular neurobiology2026

Latent HIV Infection of BBB Pericytes Enhances Gap Junction-mediated Crosstalk with Endothelial Cells.

Sarah Schmidlin, Oandy Naranjo, Silvia Torices, Nikolai Fattakhov, Monika Gilicinska, Masha Minevich, Kyra A Schindler, Destiny Tiburcio, Olivia M Osborne, Arpan Acharya and 4 more

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sarah SchmidlinDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA. sms707@miami.edu.
Oandy NaranjoDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA.
Silvia ToricesDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA.
Nikolai FattakhovDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA.
Monika GilicinskaDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA.
Masha MinevichDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA.
Kyra A SchindlerMedical Scientist Training Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Destiny TiburcioSylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Olivia M OsborneDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA.
Arpan AcharyaDepartment of Pharmacology & Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Minseon ParkDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA.
Mario StevensonDepartment of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Siddappa N ByrareddyDepartment of Pharmacology & Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Michal ToborekDepartment of Biochemistry and Molecular Biology, University of Miami Leonard M. Miller School of Medicine, Suite 528, 1011 NW 15Th Street, Miami, FL, 33136, USA. mtoborek@med.miami.edu.

Funding

NHLBI NIH HHS HL126559NIDA NIH HHS DA050528, DA059849, DA060085NIEHS NIH HHS ES036983NIMH NIH HHS MH128022, MH072567NINDS NIH HHS NS141704
6 · The paper itself

Abstract

HIV-Associated Neurocognitive Impairments persist, with over 50% of patients experiencing cognitive decline. Blood-brain barrier (BBB) impairment is a consistent feature of this comorbidity, which is remarkable, because BBB endothelial cells are not productively infected by HIV-1. Conversely, pericytes can be productively infected with HIV-1 and are essential for cerebrovascular homeostasis. Given this, we hypothesized that HIV-1 infection of pericytes disrupts BBB endothelial cell integrity through dysfunctional gap junction and hemichannel signaling, impairing pericyte-endothelial intercellular communication. Using a co-culture model with primary human BBB pericytes and brain microvascular endothelial cells, pericytes were infected with HIV-1 for 3 or 7 days, exhibiting active and latent viral phenotypes. Findings revealed enhanced gap junction communication between HIV-infected pericytes and endothelial cells under both conditions, and blocking gap junctions modulated endothelial inflammatory responses. Overall, this study advances our understanding of the molecular mechanisms underlying HIV-associated BBB dysfunction and may inform the development of targeted therapeutic strategies.

Indexed as

Blood-Brain BarrierCell CommunicationEndothelial CellsGap JunctionsHIV-1HIV InfectionsPericytesVirus LatencyCoculture TechniquesHumansAntiretroviral therapyBlood-brain barrierCentral nervous systemGap junction-mediated communicationHIV infectionNeurocognitive impairment

Identifiers

PMID42886426

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.