Evidence map›Paper›PMID 42886389›Full record

ArticleJournal of computer-aided molecular design2026

Computer-aided development of novel thiazolidinone-thiazole derivatives: multidimensional structure-activity relationships revealed by quantum chemical analysis, molecular docking and biological investigation.

Tayyiaba Iqbal, Shoaib Khan, Asrar Khan, Hassnain Sajjad, Masi A Almalki, Souhir Abid, Majdi Abid, Syed Kashif Ali, Zaripov Bakridin, Eshmuratov Baltabay and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tayyiaba IqbalDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan.
Shoaib KhanDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan. shoaibkhanswati@gmail.com.ORCID https://orcid.org/0000-0001-5404-0954
Asrar KhanDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan.
Hassnain SajjadDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan.
Masi A AlmalkiDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Souhir AbidDepartment of Chemistry, College of Science, Jouf University, P.O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi Arabia.
Majdi AbidDepartment of Chemistry, College of Science, Jouf University, P.O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi Arabia.
Syed Kashif AliDepartment of Physical Sciences, Chemistry Division, College of Science, Jazan University, P.O. Box. 114, Jazan, 45142, Kingdom of Saudi Arabia.
Zaripov BakridinDepartment of Human and animal physiology, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, Uzbekistan.
Eshmuratov BaltabayDepartment of Forensic Medicine and Medical Law (first), Tashkent Medical Academy, Tashkent, Uzbekistan.
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia.
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a major global health challenge, highlighting the need for new inhibitors of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase. In this study, a series of thiazole-based thiazolidinone derivatives (1-10) was designed, synthesized, and structurally characterized using spectroscopic techniques. Among the synthesized compounds, 8 showed the strongest inhibitory activity against α-amylase and α-glucosidase, with IC

Indexed as

alpha-AmylasesGlycoside Hydrolase InhibitorsThiazolesThiazolidinesalpha-GlucosidasesCatalytic DomainComputer-Aided DesignDensity Functional TheoryDrug DesignHumansHydrogen BondingHypoglycemic AgentsKineticsMolecular Docking SimulationStructure-Activity Relationshipalpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsThiazolesThiazolidinesADMET predictionComputer-aided drug designDensity functional theory (DFT)Diabetes mellitusEnzyme kineticsMolecular dockingThiazoleThiazolidinone

Identifiers

PMID42886389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.