ArticleJournal of the Egyptian National Cancer Institute2026
Association of XRCC6 -61 C > G and XRCC7 6721G > T polymorphisms with susceptibility to pediatric acute lymphoblastic leukemia.
Article in Journal of the Egyptian National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute lymphoblastic leukemia (ALL) is the most frequent malignancy in children. The XRCC6 and XRCC7 genes play a key role in the nonhomologous end-joining (NHEJ) repair process and may influence susceptibility to ALL. The aim of this study is to evaluate the polymorphisms XRCC6 -61 C > G (rs2267437) and XRCC7 6721G > T (rs7003908) in children with ALL. MATERIALS AND
methodsGenomic DNA was extracted from the buffy coat from whole blood samples of patients. Genotyping of XRCC6 -61 C > G and XRCC7 6721G > T polymorphisms was performed by PCR followed by restriction fragment length polymorphism (PCR-RFLP) using specific restriction enzymes (BanI and Pvu II).
resultsIn this investigation significant associations were discovered between XRCC6 -61 C > G genotypes CC (P = 0.006) and CG (P = 0.01) with ALL patients. It is important to note that while the CC genotype association remained significant after Bonferroni correction (P < 0.01), the CG genotype association was nominal (P between 0.01 and 0.05) and should be interpreted with caution. XRCC7 6721G > T genotypes GT (P = 0.02) and TT (P = 0.05) were significantly associated with ALL in males and females, respectively. In ALL patients with B-Cell subtype, XRCC6 -61 C > G genotypes CC (P = 0.04), GC (P = 0.05), and C allele (P = 0.05) showed significant associations. XRCC7 6721G > T genotypes GT (P = 0.003) and TT (P = 0.05) were also significantly associated in B-Cell ALL. Significant associations were observed for XRCC6 -61 C > G genotype CC (P = 0.04) and C allele (P = 0.03) in ALL patients with favorable cytogenetic abnormalities.
conclusionsIn conclusion, our findings suggest that the XRCC6 -61 C > G and XRCC7 6721G > T polymorphisms may be associated with susceptibility to pediatric ALL, with potential lineage-specific and cytogenetic context-dependent effects. However, given the exploratory nature of our subgroup analyses and the statistical limitations, these results should be interpreted cautiously. Large-scale, multi-center studies with functional validation are needed to confirm these associations and elucidate the underlying mechanisms.
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