Evidence map›Paper›PMID 42886315›Full record

ReviewIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2026

Outcomes of Clostridium difficile infection in liver transplant patients: A systematic review and meta-analysis.

Muhammad Shahzil, Fariha Hasan, Ammad Javaid Chaudhary, Syeda Hafsa Qadri, Muhammad Saad Faisal, Anza Muhammad, Abdullah Ejaz, Shuhaib Ali, Rimmel Ali, Oasima Muner and 2 more

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In one paragraph

Review in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Muhammad ShahzilDepartment of Internal Medicine, Penn State Health Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, PA, USA.
Fariha HasanDepartment of Gastroenterology, Cooper University Health Care, Camden, NJ, USA.
Ammad Javaid ChaudharyDepartment of Gastroenterology, Henry Ford Health, Henry Ford Hospital, Detroit, MI, USA.
Syeda Hafsa QadriDepartment of Medicine, Dow Medical College, Karachi, Pakistan.
Muhammad Saad FaisalDepartment of Gastroenterology, Henry Ford Health, Henry Ford Hospital, Detroit, MI, USA.
Anza MuhammadDepartment of Medicine, King Edward Medical University, Lahore, Pakistan.
Abdullah EjazDepartment of Medicine, King Edward Medical University, Lahore, Pakistan.
Shuhaib AliDepartment of Internal Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Rimmel AliDepartment of Medicine, Dow Medical College, Karachi, Pakistan.
Oasima MunerCooper Medical School of Rowan University, 401 Broadway, Camden, NJ, 08013, USA. oasimamuner98@gmail.com.ORCID http://orcid.org/0009-0005-1341-3714
Muhammad Ali KhaqanDepartment of Gastroenterology and Hepatology, University of Kentucky, Lexington, KY, USA.
Syed-Mohammed JafriDepartment of Gastroenterology, Henry Ford Hospital, Detroit, MI, 48,202, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClostridioides difficile infection (CDI) is a significant healthcare-associated complication, especially for liver transplant (LT) recipients who are at increased risk due to their immuno-suppressed status and antibiotic use. This systematic review and meta-analysis aimed at elucidating the outcomes of CDI in LT recipients.

methodsWe adhered to PRISMA guidelines and searched databases including CENTRAL, PubMed, Embase and Scopus until December 2024. Studies included LT recipients with and without CDI. Outcomes were pooled using meta-analytic techniques with risk ratios (RR) for dichotomous data and mean differences for continuous data.

resultsAmong 10 included studies (1,216,500 LT recipients; 3.2% with CDI), the primary pooled analysis showed no significant difference in mortality (OR, 1.34; 95% CI, 0.38-4.72; I

conclusionIn addition to a significant association between PPI use and increased risk of CDI, CDI significantly affects mortality, duration of hospital stays and pre-operative MELD scores in LT recipients, underscoring its impact on post-operative outcomes.

Indexed as

Clostridioides difficile infectionLength of stayLiver transplant recipientsMortality rates

Identifiers

PMID42886315

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.