Evidence map›Paper›PMID 42886269›Full record

ArticleMolecular biology reports2026

Harnessing microvesicles from plantaricin-enhanced stem cells to trigger apoptosis in colon cancer cells.

Amir Reza Yaghoubinezhad, Raheleh Halabian, Lila Sadat Nilchiani, Ali Najafi

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Amir Reza YaghoubinezhadResearch Center for Health Management in Mass Gathering, Red Crescent Society of the Islamic Republic of Iran, Tehran, Iran.
Raheleh HalabianApplied Microbiology Research Center, Biomedicine Technologies Institute Baqiyatallah University of Medical Sciences, Tehran, Iran. r.halabian@yahoo.com.ORCID https://orcid.org/0000-0002-3363-8276
Lila Sadat NilchianiDepartment of Molecular and Cell Biology, Faculty of Advanced Sciences and Technology, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
Ali NajafiMolecular Biology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) remains a leading cause of cancer-related mortality, necessitating the development of selective and cell-free therapeutic strategies. This study evaluated the pro-apoptotic potential of microvesicles (MVs) derived from plantaricin-preconditioned mesenchymal stem cells (MSCs) against CRC cells.

methodsHuman bone marrow-derived MSCs were preconditioned with a sub-IC

resultsPlantaricin-preconditioned MVs exhibited a reduced mean diameter (253 nm vs. 618 nm) and higher protein content (1107 vs. 983 µg/mL). These MVs significantly decreased HT-29 cell viability with a lower IC

conclusionsPlantaricin-enhanced MSC-derived MVs promoted an apoptosis-associated response in CRC cells, supporting their potential as a cell-free approach for further investigation in colorectal cancer.

Indexed as

ApoptosisBacteriocinsCell-Derived MicroparticlesColonic NeoplasmsMesenchymal Stem Cellsbcl-2-Associated X ProteinCell SurvivalHEK293 CellsHT29 CellsHumansProto-Oncogene Proteins c-bcl-2Bacteriocinsbcl-2-Associated X ProteinProto-Oncogene Proteins c-bcl-2ApoptosisCell-free therapyColorectal cancerMesenchymal stem cellsMicrovesiclesPlantaricin

Identifiers

PMID42886269

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.