Evidence map›Paper›PMID 42886260›Full record

ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2026

Association between pre-processing total protein and processing time in drop-type cell-free and concentrated ascites reinfusion therapy.

Kazuha Sagiya, Naoki Ogasawara, Shinya Inahara, Ryota Takahashi, Tomoka Hayasaka, Yuya Shimizu, Ryo Chubachi, Masakazu Suzuki, Shunsuke Kawamoto

Abstract read
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Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kazuha SagiyaCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan. ce-sagiya@hosp.tohoku-mpu.ac.jp.ORCID http://orcid.org/0009-0002-4149-517X
Naoki OgasawaraCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan. ce.n-ogasawara@hosp.tohoku-mpu.ac.jp.
Shinya InaharaCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan.
Ryota TakahashiCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan.
Tomoka HayasakaCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan.
Yuya ShimizuCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan.
Ryo ChubachiCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan.
Masakazu SuzukiCentral Medical Department Faculty of Clinical Engineering, Tohoku Medical and Pharmaceutical University Hospital, 1-12-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8512, Japan.
Shunsuke KawamotoDivision of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predicting processing time in drop-type cell-free and concentrated ascites reinfusion therapy (CART) remains difficult. We examined whether pre-processing total protein (TP) was associated with processing time after accounting for ascites amount, processing height, ascites etiology, and repeated sessions. We retrospectively analyzed 97 CART sessions in 51 patients. Log-transformed processing time was analyzed using a linear mixed-effects model including pre-processing TP, pre-processing ascites amount, processing height (140 or 200 cm), and ascites etiology as fixed effects, with patient as a random intercept. Receiver operating characteristic (ROC) analysis of pre-processing TP for an above-preferred-range session-averaged processing rate (>2,000 mL/h) was secondary and exploratory. Higher pre-processing TP (β = 0.259, 95% confidence interval (CI) 0.194-0.325; P < 0.001), greater ascites amount per 1,000 g (β = 0.270, 95% CI 0.234-0.305; P < 0.001), and 140-cm versus 200-cm processing height (β = 0.161, 95% CI 0.038-0.284; P = 0.012) were associated with longer processing time, whereas ascites etiology was not significantly associated. The overall ROC cutoff was 1.2 g/dL (area under the curve (AUC), 0.931), and the first-session AUC was 0.947 (95% CI, 0.884-1.000). Higher pre-processing TP remained significantly associated with longer processing time after accounting for ascites amount, processing height, ascites etiology, and repeated sessions. Pre-processing TP may serve as a practical workflow-oriented indicator in drop-type CART, whereas ROC-derived cutoffs should be interpreted as exploratory.

Indexed as

AscitesAscitic FluidProteinsAgedCell-Free SystemFemaleHumansMaleMiddle AgedRetrospective StudiesROC CurveTime FactorsProteinsCell-free and concentrated ascites reinfusion therapyIntermittent drop-control methodProcessing heightProcessing timeTotal protein

Identifiers

PMID42886260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.