Evidence map›Paper›PMID 42886256›Full record

ArticlePediatric surgery international2026

The impact of pathological cyst wall changes on congenital biliary dilatation in infancy.

Takeshi Shirai, Toshiharu Matsuura, Akihiko Tamaki, Shohei Maeda, Yukihiro Toriigahara, Yoshiaki Takahashi, Koichiro Yoshimaru, Kenichi Kohashi, Yoshinao Oda, Tatsuro Tajiri

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takeshi ShiraiDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0002-4418-6498
Toshiharu MatsuuraDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. matsuura.toshiharu.809@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0002-4937-3890
Akihiko TamakiDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shohei MaedaDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yukihiro ToriigaharaDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoshiaki TakahashiDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Koichiro YoshimaruDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kenichi KohashiDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoshinao OdaDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tatsuro TajiriDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the impact of pathological changes in bile duct cysts on the clinical and liver pathological findings in early infantile patients with congenital biliary dilatation (CBD).

methodIn patients with CBD who underwent definitive surgery ≤ 4 months of age, the clinical and liver pathological findings were analyzed according to the presence or absence of inflammatory and fibrotic changes on the luminal side of the bile duct cyst.

resultsAmong the 14 patients with infantile CBD, 8 had inflammatory cell infiltration (iCBD), and 4 of these 8 patients showed the formation of a collagen layer together. In the remaining six patients, no infiltration of inflammatory cells or formation of collagen layers was observed (non-iCBD). In the iCBD group, the preoperative liver biochemistry levels were higher, the cyst amylase levels were lower, and the degree of liver fibrosis was more severe than those in the non-iCBD group, with significant differences. In comparisons of iCBD patients, there were no differences in the preoperative liver biochemistry levels, cyst amylase levels, and severity of liver fibrosis between the presence and absence of a collagen layer.

conclusionInflammatory and fibrotic changes in the bile duct cysts due to obstructive cholestasis may affect the clinical and liver histopathological differences in early infantile CBD after birth.

Indexed as

Choledochal CystDilatation, PathologicFemaleHumansInfantInfant, NewbornLiverMaleRetrospective StudiesCholestasisCollagenCongenital biliary dilatationLiver fibrosis

Identifiers

PMID42886256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.