ArticleFEBS open bio2026
Ultrafast visual detection of Streptococcus suis via HtpsC-targeted LAMP-CRISPR-Cas12a coupled with lateral flow immunochromatography.
Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
This study describes a rapid, visual detection platform for Streptococcus suis, a significant zoonotic pathogen, by integrating loop-mediated isothermal amplification (LAMP) with CRISPR-Cas12a and a lateral flow immunochromatographic strip (LFIA) readout. Targeting the conserved HtpsC gene, specific LAMP primers and a PAM-compliant CrRNA were designed. Following isothermal amplification, the Cas12a/CrRNA complex recognizes the HtpsC amplicon, initiating target-specific cleavage and subsequent trans-cleavage of a dual-labeled ssDNA reporter (FAM-BIO), enabling visual detection on a LFIA; a design which reduces false positives. The optimized assay detected HtpsC-positive S. suis strains within 45 min and achieved a visual detection limit of 1.1 × 10
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