Evidence map›Paper›PMID 42885671›Full record

ArticleeLife2026

Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends.

Adhithi R Raghavan, Kieron May, Vijayalakshmi V Subramanian, Hannah G Blitzblau, Neem J Patel, Jonathan Houseley, Andreas Hochwagen

Abstract read
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In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adhithi R RaghavanDepartment of Biology, New York University, New York, United States.
Kieron MayEpigenetics Programme, Babraham Institute, Cambridge, United Kingdom.
Vijayalakshmi V SubramanianDepartment of Biology, New York University, New York, United States.
Hannah G BlitzblauDepartment of Biology, New York University, New York, United States.
Neem J PatelDepartment of Biology, New York University, New York, United States.
Jonathan HouseleyEpigenetics Programme, Babraham Institute, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-8509-1500
Andreas HochwagenDepartment of Biology, New York University, New York, United States.ORCID https://orcid.org/0000-0002-6184-443X

Funding

Mechanisms of programmed chromosome breakageR35GM148223 · NIGMS · NEW YORK UNIVERSITY · PI Andreas Hochwagen · 2023 to 2026
$2.3M
Babraham Institute BB/W509917/1Babraham Institute BI Epigenetics ISP; BBS/E/B/000C0523New York University Dean's Dissertation FellowshipNew York University Fleur Strand Graduate FellowshipNew York University Henry McCracken FellowshipNIGMS NIH HHS R35 GM148223
6 · The paper itself

Abstract

In many organisms, meiotic crossover recombination is suppressed near the extreme ends of chromosomes. Here, we show that multiple, often chromosome-specific, suppressive mechanisms with differing ranges contribute to the consistently low enrichment of recombination-promoting axis proteins and the downregulation of DNA double-strand breaks (DSBs) within 20 kb of telomeres in

Indexed as

Chromosomes, FungalDNA Breaks, Double-StrandedMeiosisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsHistone-Lysine N-MethyltransferaseNuclear ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeTelomereDot1 protein, S cerevisiaeHistone-Lysine N-MethyltransferaseNuclear ProteinsSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeaxis proteinschromatin modifierschromosomesDot1gene expressiongeneticsgenomicsmeiotic DSBsS. cerevisiaeSir complexsubtelomeres

Identifiers

PMID42885671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.