Evidence map›Paper›PMID 42885664›Full record

ArticleThoracic cancer2026

KRAS G12S Positive Non-Small Cell Lung Cancer Mimicking KRAS G12C Positivity on the AmoyDx PCR Panel: A Case Report.

Tadashi Sakaguchi, Kentaro Ito, Miho Nishio, Yuta Suzuki, Akemi Iketani, Kengo Ushiro, Osamu Hataji

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tadashi SakaguchiDepartment of Respiratory Medicine, Saiseikai Matsusaka Municipal Hospital, Matsusaka, Mie, Japan.
Kentaro ItoDepartment of Respiratory Medicine, Saiseikai Matsusaka Municipal Hospital, Matsusaka, Mie, Japan.
Miho NishioCancer Genomic Laboratory, Saiseikai Matsusaka Municipal Hospital, Matsusaka, Mie, Japan.
Yuta SuzukiDepartment of Respiratory Medicine, Saiseikai Matsusaka Municipal Hospital, Matsusaka, Mie, Japan.
Akemi IketaniDepartment of Pathology, Saiseikai Matsusaka Municipal Hospital, Matsusaka, Mie, Japan.
Kengo UshiroCancer Genomic Laboratory, Saiseikai Matsusaka Municipal Hospital, Matsusaka, Mie, Japan.
Osamu HatajiDepartment of Respiratory Medicine, Saiseikai Matsusaka Municipal Hospital, Matsusaka, Mie, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A false-positive KRAS G12C on a multi-PCR assay using the amplification refractory mutation system can potentially occur in cases harboring certain multi-nucleotide variants other than KRAS G12C. A 62-year-old man with a large left upper lobe tumor was diagnosed with lung adenocarcinoma. A multi-PCR assay by the AmoyDx Pan Lung Cancer PCR panel showed positivity for KRAS G12C and KRAS G12A/G12V/G12R/G13C. However, next-generation sequencing revealed a KRAS variant of c.34_35delinsTC (p.G12S). KRAS G12S multi-nucleotide variants may lead to false-positive KRAS G12C results on the multi-PCR assay.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPolymerase Chain ReactionProto-Oncogene Proteins p21(ras)HumansMaleMiddle AgedMutationKRAS protein, humanProto-Oncogene Proteins p21(ras)AmoyDx pan lung cancer PCR panelfalse‐positiveKRAS G12CKRAS G12Smulti‐nucleotide variants

Identifiers

PMID42885664
PMCPMC13673508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.