ArticleJournal of cachexia, sarcopenia and muscle2026
Aberrant Myelopoiesis and Haematopoietic Stem Cell Niche Remodelling Precedes Cancer Cachexia Onset in a Sex-Dependent Manner.
Article in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMale cancer patients are 30% more likely to develop cachexia compared to females; however, the underlying aetiology remains unknown. Myelopoiesis induces inflammation in cancer cachexia, which contributes to muscle atrophy. Whether differences in myelopoiesis during cancer cachexia initiation contribute to sex-based differences in cachexia incidence remains unknown.
methodsMale and female C57BL/6 and B6(C)-Ccr2
resultsLLC inoculation reduced tumour-free body weight, lean mass, gastrocnemius-soleus mass and myofiber cross-sectional area (CSA) in males at 3.5 weeks (p < 0.05), while females maintained tumour-free body weight, lean mass and CSA. Within the bone marrow, haematopoietic stem cells (HSCs) were increased at 2, 2.5 and 3.5 weeks compared to sham in males and at 2.5 weeks compared to 2 and 3.5 weeks in females (p < 0.05). Multipotent progenitors (MPPs) were significantly increased at 2, 2.5 and 3.5 weeks compared to sham in males and at 2.5 weeks compared to sham, 2 and 3.5 weeks in females (p < 0.05). Downstream, common myeloid progenitors (CMPs) and granulocyte-monocyte progenitors (GMPs) were elevated in males at 2.5 weeks, with CCR2
conclusionOur study suggests that aberrant myelopoiesis and sex-specific HSC niche remodelling precede muscle atrophy during cachexia development in males. These findings provide an important first step in understanding the role aberrant myelopoiesis plays in cancer cachexia and establish myeloid skewing as a potential therapeutic target.
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