Evidence map›Paper›PMID 42885379›Full record

ArticleResearch square2026

Symmetry-breaking antibody binding reveals extensive capsid malleability in pandemic human norovirus.

Carmen V Apostol, Ramakrishnan Anish, Son Pham, Khalil Ettayebi, Janam Dave, Frederick H Neill, Marina Bok, Banumathi Sankaran, Sue Crawford, Robert L Atmar and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carmen V ApostolThe Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.
Ramakrishnan AnishThe Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8029-5421
Son PhamThe Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.
Khalil EttayebiDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3011-4693
Janam DaveDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1979-5961
Frederick H NeillDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Marina BokIncuinta, Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, ZC, Argentina.ORCID 0000-0003-4309-8629
Banumathi SankaranBerkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley Laboratory, Berkeley, CA, USA.ORCID 0000-0002-3266-8131
Sue CrawfordDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8113-3806
Robert L AtmarDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9989-6772
James E CroweDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-0049-1079
Viviana ParreñoIncuinta, Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, ZC, Argentina.
Mary K EstesDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4813-4249
B V Venkataram PrasadThe Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1172-2071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus capsids are metastable assemblies with an exquisite balance between stability and flexibility, obligatory for entry, infectivity, and immune escape. Yet, the extent to which human viruses exploit capsid plasticity and how that consequently shapes antigenic landscapes remains poorly understood. Human noroviruses (HuNoVs) are the leading cause of acute viral gastroenteritis worldwide

Identifiers

PMID42885379
PMCPMC13662703

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.