Evidence map›Paper›PMID 42885231›Full record

ArticleChemical biology & drug design2026

Synthesis of Curcumin Analogs Targeting Androgen Receptor for the Selective Inhibition of Castration-Resistant Prostate Cancer Cells.

Manman Huang, Ziyi Chen, Ruiqi Zhang, Shengping Liu, Defeng Xu, Bing Li, Hang Hu

Abstract read
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Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manman HuangSchool of Pharmacy, Changzhou University, Changzhou, P. R. China.
Ziyi ChenSchool of Pharmacy, Changzhou University, Changzhou, P. R. China.
Ruiqi ZhangSchool of Pharmacy, Changzhou University, Changzhou, P. R. China.ORCID https://orcid.org/0009-0002-3164-0695
Shengping LiuSchool of Pharmacy, Changzhou University, Changzhou, P. R. China.
Defeng XuSchool of Pharmacy, Changzhou University, Changzhou, P. R. China.ORCID https://orcid.org/0000-0003-0506-1876
Bing LiSchool of Pharmacy, Changzhou University, Changzhou, P. R. China.
Hang HuSchool of Pharmacy, Changzhou University, Changzhou, P. R. China.ORCID https://orcid.org/0000-0003-1646-7951

Funding

Jiangsu Provincial Engineering Research Center for Drug Intelligent Manufacturing and Precision Delivery MDP1028002
6 · The paper itself

Abstract

In the present study, a series of curcumin analogs (A1-P3) were designed and synthesized for the inhibition of prostate cancer cells by targeting androgen receptor (AR). All synthesized compounds were structurally characterized by

Indexed as

Androgen Receptor AntagonistsAntineoplastic AgentsCurcuminProstatic Neoplasms, Castration-ResistantReceptors, AndrogenCell Line, TumorCell SurvivalHumansMaleMolecular Docking SimulationStructure-Activity RelationshipAndrogen Receptor AntagonistsAntineoplastic AgentsCurcuminReceptors, Androgenandrogen receptorcurcumin analogsprostate cancerselectivitystructure–activity relationship

Identifiers

PMID42885231

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.