Evidence map›Paper›PMID 42885142›Full record

ArticleImmunity, inflammation and disease2026

Effects of Cd8a Gene Knockout on Gut Microbiota and Liver Metabolism.

Zhongshi Dai, Chuan Wang, Hu Mu, Chunxiu Hou, Jing Tang, Jinhai Ma, Mingxing Zhu, Bingshuo Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhongshi DaiSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.ORCID https://orcid.org/0009-0001-4193-9220
Chuan WangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Hu MuKey Laboratory of Common Infectious Disease Prevention and Control in Ningxia, Yinchuan, Ningxia, China.
Chunxiu HouSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Jing TangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.
Jinhai MaGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.ORCID https://orcid.org/0000-0001-8151-0165
Mingxing ZhuSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, China.ORCID https://orcid.org/0009-0005-4065-0475
Bingshuo QianKey Laboratory of Common Infectious Disease Prevention and Control in Ningxia, Yinchuan, Ningxia, China.ORCID https://orcid.org/0009-0004-9823-344X

Funding

The Ningxia Natural Science Foundation 2025AAC030657The Ningxia Natural Science Foundation 2026AAC031166the Open Research Project of the Key Laboratory of Prevention and Treatment of Common Infectious Diseases in Ningxia 2023-KF003the Open Research Project of the Key Laboratory of Prevention and Treatment of Common Infectious Diseases in Ningxia 2024-KF003
6 · The paper itself

Abstract

objectiveEvaluate the effects of CD8

methodsThe Cd8a gene was knocked out in mice to generate Cd8a knockout mice. Genotypes were identified using polymerase chain reaction (PCR) and agarose gel electrophoresis. Mice were divided into three groups: normal control, CD8

resultsWe found that CD8

conclusionCD8

Indexed as

CD8 AntigensCD8-Positive T-LymphocytesGastrointestinal MicrobiomeLiverAnimalsMiceMice, Inbred C57BLMice, KnockoutRNA, Ribosomal, 16SCD8 antigen, alpha chainCD8 AntigensRNA, Ribosomal, 16SCD8+ T cellsgut microbesliver metabolism

Identifiers

PMID42885142
PMCPMC13673008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.