ArticlePolymers2026
Lignin-Hydroxypropyl-β-Cyclodextrin Matrix for Chlorzoxazone Loading and Release: Physicochemical, Antioxidant, and Antimicrobial Characterization.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Chlorzoxazone (CLZ) is a poorly water-soluble drug whose formulation may benefit from carrier systems capable of drug incorporation and controlled release. This study investigated an epichlorohydrin (ECH)-mediated lignin-hydroxypropyl-β-cyclodextrin (LIG/HP-β-CD) matrix for CLZ loading and release and evaluated its physicochemical, antioxidant, and antimicrobial characteristics. The resulting material was characterized by Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TG/DTG), while CLZ release was evaluated using kinetic models. The experimentally determined CLZ loading was 41.8 mg/g, corresponding to a loading efficiency of 20.9% relative to the initially added drug. After 180 min, the cumulative amount released reached 29.81 mg/g, corresponding to 71.32% of the loaded CLZ. The release profile was adequately described by the Weibull model (R
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