ReviewPolymers2026
Functional Polymer-Based Biomaterials for Corneal Tissue Engineering: An Indication-Guided Review of Design Trade-Offs.
Review in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Corneal disease is a cause of vision loss worldwide, while conventional keratoplasty is constrained by limited donor tissue and immune rejection. This indication-guided review examines functional polymer platforms for corneal tissue engineering, including natural polymers, synthetic polymer networks and scaffolds, and hybrid polymer composites. It examines how molecular composition, crosslinking, architecture, surface functionalization, and fabrication influence hydrogels, films, fibrous scaffolds, injectable matrices, delivery systems, and polymeric keratoprosthetic components for epithelial, stromal, and endothelial contexts. Using an indication-guided design trade-off framework, the review compares these systems across optical performance, mechanical performance and surgical handling, mass transport and degradation behavior, biological function and tissue integration, host response, and manufacturability. Natural polymers can provide biological cues that support cell interactions, with limitations in mechanical robustness and compositional consistency. Synthetic polymers offer greater control of network properties and processing but often require biofunctionalization to support tissue integration. Hybrid constructs can distribute optical, structural, and therapeutic functions across components or regions, with added fabrication complexity. No material class is universally optimal, and polymer selection should be guided by the target corneal layer and clinical indication. Standardized evaluation, reproducible reporting of polymer composition and fabrication conditions, scalable manufacturing, and transparent reporting of evidence maturity are priorities for clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.