Evidence map›Paper›PMID 42884733›Full record

ArticleNutrients2026

Sulforaphane Alleviates α-Amanitin-Induced Liver Injury by Modulating Pink1-Parkin Pathway.

Jian Sun, Yangyang Li, Zehui Li, Zhijie Liu, Zhengwang Yi, Peng Wu, Juyu Wang, Weijie Qu, Bundit Tengjaroenkul, Yi Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jian SunDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Yangyang LiDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Zehui LiDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Zhijie LiuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Zhengwang YiDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Peng WuYunnan Plateau Characteristic Agricultural Industry Research Institute, Yunnan Agricultural University, Kunming 650201, China.
Juyu WangDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Weijie QuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Bundit TengjaroenkulFaculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Yi WuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.
Xiaolong GuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No. 95, Panlong District, Kunming 650051, China.

Funding

Department of Science and Technology of Yunnan Province 202304BI090007Department of Science and Technology of Yunnan Province 202403AK140037Department of Science and Technology of Yunnan Province 202503AP140043Department of Science and Technology of Yunnan Province 202505AP120023
6 · The paper itself

Abstract

backgroundα-Amanitin (α-AMA) is the primary lethal toxin found in poisonous mushrooms of the genus Amanita; accidental ingestion can lead to severe liver injury, and there is currently no specific antidote. Due to its significant anti-inflammatory and antioxidant activity, Sulforaphane (SFN) has attracted increasing attention for its role in preventing liver injury. However, it remains unclear whether SFN can alleviate α-AMA-induced liver injury. This study aimed to elucidate the protective effects of SFN against α-AMA-induced liver injury and its potential molecular mechanisms. METHODS AND

resultsThe results showed that SFN significantly reduced serum ALT and AST levels in α-AMA-intoxicated mice (

conclusionsThe above results indicate that SFN may alleviate α-AMA-induced liver damage by promoting the expression of Pink1 and Parkin, improving mitochondrial dysfunction, and inhibiting apoptosis.

Indexed as

Alpha-AmanitinChemical and Drug Induced Liver InjuryIsothiocyanatesProtein KinasesSulfoxidesUbiquitin-Protein LigasesAnimalsAntioxidantsApoptosisCell LineLiverMaleMiceOxidative StressPTEN-Induced Putative KinaseSignal TransductionAlpha-AmanitinAntioxidantsIsothiocyanatesparkin proteinProtein KinasesPTEN-Induced Putative KinasesulforaphaneSulfoxidesUbiquitin-Protein Ligasesapoptosisoxidative stressPink1-ParkinSulforaphane (SFN)α-amanitin (α-AMA)

Identifiers

PMID42884733
PMCPMC13666618

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.