Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial.

Chisane Kujirai, Hirotsugu Oda, Miyuki Tanaka, Yayoi Sugimori

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chisane KujiraiR&D Division, Food Function Research Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama 252-8583, Kanagawa, Japan.

Hirotsugu OdaR&D Division, Food Function Research Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama 252-8583, Kanagawa, Japan.ORCID 0000-0002-2661-1585

Miyuki TanakaR&D Division, Food Function Research Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama 252-8583, Kanagawa, Japan.ORCID 0000-0002-7670-7366

Yayoi SugimoriDepartment of Obstetrics and Gynecology, Bunkyo Garden Women's Clinic, 2F, 1-1-7 Koishikawa, Tokyo 112-0002, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study investigated the effects of bovine lactoferrin (LF) on vaginal microbiota in healthy postmenopausal women.

methodsA randomized, double-blind, placebo-controlled trial was conducted. Healthy Japanese postmenopausal women were administered a placebo or bovine LF (300 mg/day) for 12 weeks. The primary endpoint was the Nugent score and the secondary endpoints were the Nugent sub-scores. The exploratory outcomes included vaginal immunoglobulin and urinary deoxypyridinoline levels.

resultsEighty participants were randomized (placebo,

conclusionsAlthough oral LF supplementation did not significantly affect the primary endpoint (overall Nugent score), a lower Gardnerella/Bacteroides morphotype score and higher vaginal IgG1 levels were observed. As these findings were derived from secondary and exploratory analyses, respectively, they are considered hypothesis-generating and require confirmation in future studies.

Indexed as

LactoferrinMicrobiotaPostmenopauseVaginaAgedAmino AcidsAnimalsCattleDouble-Blind MethodFemaleHumansImmunoglobulin GMiddle AgedAmino AcidsdeoxypyridinolineImmunoglobulin GLactoferrinbacterial vaginosislactoferrinNugent scorepostmenopausal womenvaginal microbiota

Identifiers

PMID42884644

DOI10.3390/nu18193193

PMCPMC13666833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.