Evidence map›Paper›PMID 42884629›Full record

ArticleNutrients2026

Salinee Naewla, Puncharatsm Pannin, Papatchaya Sintow, Ram Prajit, Nataya Sritawan, Apiwat Sirichoat, Rawiwan Charoensup, Peter Wigmore, Jariya Umka Welbat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Salinee NaewlaDepartment of Basic Medical Science, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand.
Puncharatsm PanninNeurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Papatchaya SintowNeurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Ram PrajitNeurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Nataya SritawanNeurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Apiwat SirichoatNeurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Rawiwan CharoensupSchool of Integrative Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand.ORCID 0000-0001-6433-0293
Peter WigmoreSchool of Life Sciences, Medical School, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
Jariya Umka WelbatNeurogenesis Research Group, Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0002-2872-1542

Funding

Khon Kaen University IN69047
6 · The paper itself

Abstract

BACKGROUND/

objectivesAccumulation of oxidative damage and brain inflammation plays a role in aging-associated memory impairment. D-galactose (D-gal) is a monosaccharide used to induce aging in rat models by promoting oxidative damage and neuroinflammation.

methodsForty-eight male Sprague-Dawley (SD) rats, two months old, were randomly assigned to eight groups: vehicle (0.9% normal saline), D-gal (50 mg/kg), PD (75, 100, and 150 mg/kg), or D-gal (50 mg/kg) co-administered with PD (75, 100 or 150 mg/kg). Spatial memory was assessed using the novel object location (NOL) test. Hippocampal neurogenesis and vascular-associated cell proliferation in the DG were evaluated using immunofluorescence staining for the co-localization of the markers Ki-67/rat endothelial cell antigen-1 (RECA-1) and 5-bromo-2'-deoxyuridine/neuronal nuclear protein (BrdU/NeuN), as well as doublecortin (DCX).

resultsRats treated with D-gal alone did not show a significant preference for the novel location. Additionally, D-gal treatment reduced the numbers of Ki-67-, Ki-67/RECA-1-, BrdU/NeuN-, and DCX-stained cells in the hippocampus. Conversely, co-administration of PD fruit extract was associated with a significant preference for the novel location, and this treatment also attenuated the D-gal-triggered reductions in cellular markers.

conclusionsThese finding suggest that PD fruit extract exerts a neuroprotective effect against D-gal-induced brain aging, potentially preserving spatial memory-related performance in rats.

Indexed as

AgingFruitHippocampusMemory DisordersNeurogenesisPlant ExtractsPrunus domesticaAnimalsCell ProliferationDentate GyrusDisease Models, AnimalDoublecortin Domain ProteinsDoublecortin ProteinGalactoseMaleNeuronsDcx protein, ratDoublecortin Domain ProteinsDoublecortin ProteinGalactoseNeuroprotective AgentsPlant ExtractsagingD-galactosehippocampal neurogenesismemoryPrunus domestica L.

Identifiers

PMID42884629
PMCPMC13667149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.