Evidence map›Paper›PMID 42884609›Full record

Trial reportNutrients2026

Effect of a Phenotype-Tailored Lifestyle Intervention on Caloric Intake and Macronutrient Composition in Adults with Obesity: A Secondary Analysis of the PHENO-Diet Trial.

Maria Antonia Espinosa, Lindsey Sefried, Jose Villamarin, Lizeth Cifuentes, Thomas Fredrick, Diego Anazco, Sima Fansa, Jamie Friend, Thomas M Rieck, Michael Camilleri and 4 more

Abstract readClinical Trial
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Antonia EspinosaPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0006-2018-4734
Lindsey SefriedPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Jose VillamarinPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Lizeth CifuentesPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-7865-2947
Thomas FredrickPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-2906-1574
Diego AnazcoPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1829-7001
Sima FansaPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Jamie FriendPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Thomas M RieckHealthy Living Program, Integrative Medicine and Health, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-5668-5454
Michael CamilleriPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6472-7514
Maria D Hurtado AndradePrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-2322-7334
Matthew M ClarkPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3887-4419
Donald D HensrudPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-6980-2245
Andres AcostaPrecision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Funding

Phenotype-Tailored Lifestyle intervention for Obesity: A Randomized TrialR01DK139028 · NIDDK · MAYO CLINIC ROCHESTER · PI Andres J Acosta · 2024 to 2026
$2.0M
Mechanisms of Enteroendocrine L-Cell Dysfunction and Bile Adaptations to Weight LossK23DK114460 · NIDDK · MAYO CLINIC ROCHESTER · PI ACOSTA, ANDRES J · 2018 to 2022
$980k
Dairy Management N/AMayo Clinic Foundation N/ANIDDK NIH HHS K23 DK114460NIDDK NIH HHS R01 DK139028NIH HHS 5K23DK114460-22NIH HHS 5R01DK139028-25
6 · The paper itself

Abstract

BACKGROUND/

objectivesA 12-week trial demonstrated that phenotype-tailored lifestyle intervention (PLI) was associated with greater weight loss than standard lifestyle intervention (SLI); however, differences in dietary patterns between groups were not examined.

methodsThis secondary analysis evaluated caloric and macronutrient intake at 12 weeks in adults with obesity (BMI ≥ 30 kg/m

resultsGroups were compared at 12 weeks adjusting for baseline values. PLI was associated with lower total energy intake than SLI (1273 ± 182 vs. 1894 ± 176 kcal/day;

conclusionsPLI was associated with lower energy intake, mainly due to reduced carbohydrate and fat intake, and a higher relative contribution of protein, consistent with phenotype-based recommendations rather than macronutrient prescriptions. These findings suggest a potential role for personalized dietary approaches in obesity management. However, the non-randomized design does not allow causal inferences.

Indexed as

Energy IntakeLife StyleNutrientsObesityAdultEmotional EatingEnergy MetabolismFemaleHumansMaleMiddle AgedPhenotypeSatiationWeight Lossdietary intakelifestyle interventionmacronutrientsobesityphenotypesprecision medicine

Identifiers

PMID42884609
PMCPMC13666677

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.