Evidence map›Paper›PMID 42884588›Full record

ArticleNutrients2026

Host-Microbiota Interactions in Adolescents with Severe Anorexia Nervosa: Linking Gut Dysbiosis, Intestinal Barrier Function and Microbial Metabolism.

Livia Gargiullo, Federica Del Chierico, Maria Rosaria Marchili, Mariangela Irrera, Italo Pretelli, Matteo Scanu, Francesca Toto, Annalisa Grandin, Rosaria Marotta, Cristina Mascolo and 6 more

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Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Livia GargiulloGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0003-0316-6359
Federica Del ChiericoUnit of Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.ORCID 0000-0002-4204-4736
Maria Rosaria MarchiliGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-6787-8198
Mariangela IrreraGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0009-0002-3274-9756
Italo PretelliAnorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Matteo ScanuUnit of Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.ORCID 0000-0001-6266-2884
Francesca TotoUnit of Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.
Annalisa GrandinGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Rosaria MarottaGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Cristina MascoloGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Flavia CirilloGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Valentina ColistraGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Ludovica RicciPediatrics Residency Program, Department of Pediatrics, University of Rome Tor Vergata, 00133 Rome, Italy.
Valeria ZannaAnorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Lorenza PutignaniDepartment of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy.ORCID 0000-0003-0134-2830
Alberto VillaniGeneral Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-9120-0424

Funding

Ministry of Health RC2025_IMMUNO_GARGIULLO, RC2025_INNOV_DELCHIERICO
6 · The paper itself

Abstract

backgroundAnorexia nervosa (AN) is increasingly recognized as a multisystem disorder involving complex host-microbiota interactions, yet prospective pediatric studies with a comprehensive, longitudinal characterization of host-microbiota interactions remain scarce.

methodsIn this prospective longitudinal study, 26 adolescents with severe AN were evaluated at hospital admission (T0), after one month (T1), and after three months of inpatient nutritional rehabilitation (T2). Gut microbiota composition was assessed by 16S rRNA sequencing and compared with healthy controls (HC) at the baseline; predicted functional profiling was performed using PICRUSt2. Serum and urinary biomarkers of intestinal barrier integrity and microbial metabolism, routine clinical and biochemical parameters, and psychometric scores (CDI-2, MASC-2) were evaluated longitudinally using linear mixed-effects models.

resultsAt the baseline, adolescents with AN showed reduced bacterial richness compared with healthy controls, with significantly lower Chao1 diversity (

conclusionsGut microbiota and host-derived biomarkers evolve dynamically during nutritional rehabilitation in adolescents with severe AN, supporting their potential role as complementary tools for monitoring biological recovery.

Indexed as

Anorexia NervosaDysbiosisGastrointestinal MicrobiomeAdolescentBacteriaBiomarkersFemaleHumansIntestinal Barrier FunctionLongitudinal StudiesMaleProspective StudiesRNA, Ribosomal, 16SBiomarkersRNA, Ribosomal, 16Sanorexia nervosabiomarkersgut–brain axisgut microbiotaintestinal permeabilitynutritional rehabilitation

Identifiers

PMID42884588
PMCPMC13666687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.