ArticleSensors (Basel, Switzerland)2026
An Intrinsic Optical Fiber Uric Acid Sensor Using a Molecularly Imprinted Chitosan Membrane-Coated Optical Fiber as a Transducer.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An intrinsic optical fiber uric acid (UA) sensor has been developed using a molecularly imprinted chitosan (MIC) membrane-coated optical fiber as a transducer. The MIC was prepared by crosslinking chitosan with glutaraldehyde as a crosslinking reagent and UA as the template molecule. After an MIC membrane was coated on the surface of a bent optical fiber probe (BOFP), the template UA molecules were washed out of the membrane by using a diluted ammonia solution (0.10 M). This MIC membrane-coated BOFP was deployed into a sample solution for analyzing UA concentration. UA in the sample solution was selectively extracted/concentrated into the MIC membrane, while interference species in the sample solution were blocked from entering into the membrane. UA extracted into the MIC membrane was detected by passing a light beam through the BOFP and the intrinsic optical absorption signal at 315 nm by UA itself was detected as a sensing signal. There is no chemical reaction involved, and no chemical reagent is needed when using this sensor to analyze UA in a sample solution. Compared with a bare fiber BOFP, MIC membrane extraction of UA from a sample solution increased the sensor's sensitivity by 1.0 × 10
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