Evidence map›Paper›PMID 42884291›Full record

ReviewSensors (Basel, Switzerland)2026

Artificial Intelligence Enabled Dielectric Fingerprinting of Arrhythmogenic Substrates: A Precision Paradigm for Tissue Characterization Guided Cardiac Electrophysiology.

Lakshmi Sree Pugalenthi, Sidhartha Gautam Senapati, Divyanshi Sood, Areesh Fatima Sahito, Bargavi Kathirvel, Avni Arora, Kaaviyashri Saraboji, Anmolpreet Kaur, Simardeep Kaur Bumrah, Manjunath Krishnappa and 15 more

Abstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Lakshmi Sree PugalenthiDepartment of Internal Medicine, Mercy Catholic Medical Center, Philadelphia, PA 19143, USA.
Sidhartha Gautam SenapatiDepartment of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA.
Divyanshi SoodDepartment of Internal Medicine, UCHealth Parkview Medical Center, Pueblo, CO 81003, USA.
Areesh Fatima SahitoDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Bargavi KathirvelDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0009-2020-2316
Avni AroraDepartment of Clinical Neuroscience, Virginia Tech, Blacksburg, VA 24061, USA.
Kaaviyashri SarabojiDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0000-7884-2505
Anmolpreet KaurDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0005-9912-9772
Simardeep Kaur BumrahDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Manjunath KrishnappaDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Jieun LeeDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Mohammed Naveed ShariffDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0009-0004-2430-7370
Gayathri YerrapragadaDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Poonguzhali ElangovanDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-9628-7090
Sancia Mary Jerold WilsonDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Jayavinamika Jayapradhaban KalaDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Shuvashis DeyMicrowave Engineering & Imaging Laboratory (MEIL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7435-6681
Dipankar MitraMicrowave Engineering & Imaging Laboratory (MEIL), Mayo Clinic, Jacksonville, FL 32224, USA.
Shiva Sankari KaruppiahDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Rashi BilgaiyanDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Suganti ShivaramDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.
Scott A HelgesonDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7590-2293
Christopher V DeSimoneDivision of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Elena G TolkachevaDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1624-5793
Shivaram P ArunachalamDigital Engineering & Artificial Intelligence Laboratory (DEAL), Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-3251-5415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectrical and dielectric properties of the myocardium depend on its composition, fibrosis, edema, ischemia, and heat damage, and hence may play an important role in defining the electrophysiologic substrate. Local impedance and other impedance-based methods give information about these parameters that is available to clinicians, but not direct or substitutable for intrinsic conductivity and permittivity of the tissue. The use of artificial intelligence has been thoroughly studied for the ECGs, electrograms, images, and computational data analysis, but not for dielectric or impedance measurements.

objectiveThe study aims to review the scientific basis of dielectric properties of heart muscle critically in cardiology and electrophysiology, to differentiate between existing clinical and conceptual applications of myocardial dielectrics, and to estimate current and potential contributions of artificial intelligence to their interpretation. DATA SOURCES AND STUDY SELECTION: The current work represents a structured narrative review in PubMed, Scopus, and Google Scholar databases from inception until May 2026 based on various combinations of keywords that refer to myocardial impedance, dielectric properties, conductivity, permittivity, local impedance, dielectric imaging, cardiac electrophysiology, catheter ablation, machine learning, and artificial intelligence. This review included experimental, ex vivo, animal, computational, and human studies related to myocardial dielectric properties and their use in electrophysiology. Evidence was classified according to four categories: direct human clinical evidence; preclinical/translation evidence; indirect evidence from related techniques; and extrapolation concept. As a result of heterogeneity between studies, sensing technologies, and outcomes, the results have been analyzed narratively. KEY

findingsEvidence regarding the usage of AI algorithms, which have been primarily trained on myocardial dielectric or catheter-based local impedance data, is extremely scarce and mostly consists of preclinical or ex vivo data. On the contrary, the majority of clinically used AI algorithms in the field of electrophysiology make use of ECG data, intracardiac electrogram data, image processing, or computational modeling without any inputs related to dielectrics or local impedance. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: Dielectric sensing is an attractive supplement to traditional methods of voltage mapping and imaging, although the clinical readiness of dielectric sensing greatly varies depending on the application. At the present time, the existing data provide a basis for utilizing the local impedance measurement in the ablation procedure and evaluation of the myocardium properties, while the combination of artificial intelligence and dielectric sensing is still experimental. Before being introduced into the clinical electrophysiology practice, signal acquisition standardization and prospective multicenter trials are needed.

Indexed as

Arrhythmias, CardiacArtificial IntelligenceHeartAnimalsElectric ImpedanceElectrocardiographyHumansMyocardiumartificial intelligencecardiac arrhythmiascardiac electrophysiologydielectric propertieslocal impedancemyocardial tissue characterization

Identifiers

PMID42884291
PMCPMC13667509

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.