Evidence map›Paper›PMID 42884177›Full record

Trial reportInternational journal of molecular sciences2026

Beyond Taxonomy: Fungal Nutraceutical Supplementation Modifies the Functional Potential of the Gut Microbiome in Colorectal Cancer.

Nahir Rodríguez-Costas, Arturo Rodríguez-Blanco, Cristina Regueiro Expósito, Joaquín Cubiella, Esteban Sinde Stompel, Catalina Fernández-de-Ana Portela, Astrid Irene Diez Martín, Pablo Taboada-Rodríguez, Belén Fontán Silva, María Dolores Rodríguez Fernández and 8 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nahir Rodríguez-CostasMicrobiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), 36312 Vigo, Spain.ORCID 0009-0005-5670-1898
Arturo Rodríguez-BlancoHifas da Terra S.L., 36154 Pontevedra, Spain.ORCID 0000-0003-3103-2710
Cristina Regueiro ExpósitoResearch Group in Gastrointestinal Oncology Disease in Ourense, 32005 Ourense, Spain.ORCID 0000-0002-8567-6784
Joaquín CubiellaResearch Group in Gastrointestinal Oncology Disease in Ourense, 32005 Ourense, Spain.ORCID 0000-0002-9994-4831
Esteban Sinde StompelHifas da Terra S.L., 36154 Pontevedra, Spain.
Catalina Fernández-de-Ana PortelaHifas da Terra S.L., 36154 Pontevedra, Spain.ORCID 0000-0003-0411-4382
Astrid Irene Diez MartínResearch Group in Gastrointestinal Oncology Disease in Ourense, 32005 Ourense, Spain.ORCID 0000-0001-8822-2991
Pablo Taboada-RodríguezEscuela Técnica Superior de Ingeniería (ETSE), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0009-0005-0139-9951
Belén Fontán SilvaMicrobiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), 36312 Vigo, Spain.
María Dolores Rodríguez FernándezMicrobiology Department, Complexo Hospitalario Universitario de Vigo (CHUVI), 36312 Vigo, Spain.
Sara ZarraquiñosDepartment of Gastroenterology, Hospital Universitario de Ourense, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 32005 Ourense, Spain.
David RemediosDepartment of Gastroenterology, Hospital Universitario de Ourense, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 32005 Ourense, Spain.ORCID 0000-0003-2682-0317
Cristina Alejandra Sánchez GómezDepartment of Gastroenterology, Hospital Universitario de Ourense, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 32005 Ourense, Spain.ORCID 0000-0003-0924-2295
Sara Alonso LorenzoResearch Group in Gastrointestinal Oncology Disease in Ourense, 32005 Ourense, Spain.
Romina Fernández PoceiroResearch Group in Gastrointestinal Oncology Disease in Ourense, 32005 Ourense, Spain.
María Luisa de Castro PargaResearch Group in Gastrointestinal Oncology Disease in Ourense, 32005 Ourense, Spain.ORCID 0000-0001-7848-7910
Vicent Hernández RamírezResearch Group in Gastrointestinal Oncology Disease in Ourense, 32005 Ourense, Spain.ORCID 0000-0003-1607-0831
Sonia Pérez-CastroMicrobiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), 36312 Vigo, Spain.ORCID 0000-0003-1734-1904

Funding

Centre for Industrial Technological Development N.º Solicitud SOL-00105490, N.º Expediente EXP0010549
6 · The paper itself

Abstract

The gut microbiome is increasingly recognized as an important determinant of host immune regulation, intestinal homeostasis, and recovery after colorectal cancer (CRC) surgery. Although our previous randomized, double-blind, placebo-controlled clinical trial demonstrated that fungal nutraceutical supplementation with Micodigest

Indexed as

Colorectal NeoplasmsDietary SupplementsFungiGastrointestinal MicrobiomeAgedFecesFemaleHumansMaleMetagenomicsMiddle Agedcolorectal cancerfunctional metagenomicsfungal nutraceuticalsgut microbiomeinflammation

Identifiers

PMID42884177
PMCPMC13665136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.