ArticleInternational journal of molecular sciences2026
Changes in Isthmin-1, Irisin, and the AGE-RAGE Axis Following LSG: A Prospective Single-Center Cohort Study.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This prospective single-center cohort study evaluated changes in serum levels of novel adipokines and myokines, including isthmin-1 and irisin, as well as the advanced glycation end product (AGE)-soluble receptor for AGE (sRAGE) axis and monomeric C-reactive protein (mCRP) in patients with obesity before and 5 months after laparoscopic sleeve gastrectomy (LSG). The study included 38 patients with obesity (26 females and 12 males) with a median age of 42 years who underwent LSG. Laboratory parameters were assessed using commercially available immunoenzymatic assays. We observed a significant decrease in isthmin-1 concentration at the postoperative time point (Me = 2.10 ng/mL vs. Me = 1.93 ng/mL,
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