Observational studyInternational journal of molecular sciences2026
Preoperative Serum Transient Receptor Potential Ankyrin 1 (TRPA1) Levels in Class III Obesity: A Prospective Controlled Observational Study.
Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Transient Receptor Potential Ankyrin 1 (TRPA1) is a membrane cation channel activated by oxidative stress products that are chronically elevated in class III obesity. Although tissue-level TRPA1 biology is increasingly well described, the biological meaning of circulating immunoreactive TRPA1 remains poorly established. This single-centre, prospective, controlled observational study compared preoperative serum TRPA1 between adults with class III obesity scheduled for laparoscopic sleeve gastrectomy and contemporaneous controls, and explored metabolic and inflammatory correlates of the circulating signal. Serum TRPA1 was quantified by enzyme-linked immunosorbent assay (ELISA) in 42 consecutive surgical candidates and 36 controls. The primary analysis used continuous (log-transformed) TRPA1 with age- and sex-adjusted logistic regression; ROC-derived dichotomisation was retained only as an exploratory analysis. Serum TRPA1 did not differ between groups (median 309.8 vs. 340.5 pg/mL; Mann-Whitney U,
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