Evidence map›Paper›PMID 42884118›Full record

ArticleInternational journal of molecular sciences2026

Poly-L-Lactic Acid Attenuates Fibrotic Remodeling During Cutaneous Wound Healing.

Kyung-A Byun, Hyoung Moon Kim, Seyeon Oh, Ki Woong Yu, Ji Min Lee, Kuk Hui Son, Kyunghee Byun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kyung-A ByunDepartment of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.ORCID 0000-0001-7486-9137
Hyoung Moon KimDepartment of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.ORCID 0000-0001-9068-5813
Seyeon OhFunctional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.
Ki Woong YuDepartment of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.
Ji Min LeeDirector Global Clinic Gangnam, Seoul 06611, Republic of Korea.
Kuk Hui SonDepartment of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University, Incheon 21565, Republic of Korea.ORCID 0000-0002-0595-5645
Kyunghee ByunDepartment of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.ORCID 0000-0001-8678-8932

Funding

LIBON Inc. GCU-202502080001
6 · The paper itself

Abstract

Pathological hypoxia following cutaneous injury is a critical driver of wound chronicity and fibrotic remodeling. The nuclear receptor binding SET domain protein 2 (NSD2)/lysine demethylase 2A (KDM2A)-histone H3 lysine 36 dimethylation (H3K36me2) axis is a known regulator of hypoxia-induced epithelial-to-mesenchymal transition (EMT) in malignancy; however, its role in skin repair remains largely unexplored. We investigated whether poly-L-lactic acid (PLLA) could attenuate fibrotic remodeling by modulating the NSD2/KDM2A-H3K36me2 axis and examining angiogenic signaling. We used a murine 9 mm punch-wound model for in vivo assessment and HaCaT keratinocytes and human dermal fibroblasts (HDFs) exposed to 2% O

Indexed as

PolyestersSkinWound HealingAnimalsEpithelial-Mesenchymal TransitionFibroblastsFibrosisHaCaT CellsHistonesHumansJumonji Domain-Containing Histone DemethylasesKeratinocytesMaleMiceMice, Inbred C57BLSignal TransductionHistonesJumonji Domain-Containing Histone DemethylasesPolyesterspoly(lactide)Collagen remodelingEpithelial–mesenchymal transitionHypoxiaPoly-L-lactic acid

Identifiers

PMID42884118
PMCPMC13665362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.