Evidence map›Paper›PMID 42884108›Full record

ArticleInternational journal of molecular sciences2026

HBOCpred: An Ensemble Framework for Prioritisation of Germline Missense Variants in Hereditary Breast and Ovarian Cancer.

Mustafa Tarık Alay, Haktan Bağış Erdem

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mustafa Tarık AlayDepartment of Medical Genetics, Ankara Etlik City Hospital, 06170 Ankara, Türkiye.ORCID 0000-0002-1563-2292
Haktan Bağış ErdemDepartment of Medical Genetics, Ankara Etlik City Hospital, 06170 Ankara, Türkiye.ORCID 0000-0002-4391-1387

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HBOCpred was developed to support research prioritisation of unresolved germline missense variants in a defined 17-gene study panel. Four calibrated learners provide vote states (V0-V4) and a continuous modified adaptive classifier score (S

Indexed as

Breast NeoplasmsComputational BiologyGerm-Line MutationHereditary Breast and Ovarian Cancer SyndromeMutation, MissenseOvarian NeoplasmsFemaleGenetic Predisposition to DiseaseHumansensemble learninghereditary breast and ovarian cancermachine learningmissense variantvariant of uncertain significancevariant prioritisation

Identifiers

PMID42884108
PMCPMC13665518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.