LOH, LST, and TAI Profiles in Solid Tumors Harboring Pathogenic or Likely Pathogenic

Suleyman Erdogdu, Busra Ekinci, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Ibrahim Meteoglu

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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Suleyman ErdogduDepartment of Medical Oncology, Aydin City Hospital, Efeler, Aydin 09020, Türkiye.

Busra EkinciDepartment of Medical Pathology, School of Medicine, Aydin Adnan Menderes University, Efeler, Aydin 09010, Türkiye.ORCID 0000-0003-1031-6853

Seda Orenay-BoyaciogluDepartment of Medical Genetics, School of Medicine, Aydin Adnan Menderes University, Efeler, Aydin 09010, Türkiye.ORCID 0000-0003-1651-1940

Olcay BoyaciogluFaculty of Engineering, Aydin Adnan Menderes University, Efeler, Aydin 09010, Türkiye.ORCID 0000-0003-0436-3020

Ibrahim Halil ErdogduDepartment of Medical Pathology, School of Medicine, Aydin Adnan Menderes University, Efeler, Aydin 09010, Türkiye.ORCID 0000-0002-5445-2649

Ibrahim MeteogluDepartment of Medical Pathology, School of Medicine, Aydin Adnan Menderes University, Efeler, Aydin 09010, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homologous recombination deficiency (HRD) is a critical indicator of genomic instability; however, the composite HRD score may not reflect the distribution of distinct genomic scar components underlying this phenotype. In this exploratory study, we compared the absolute and relative contributions of loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) among solid tumors harboring pathogenic or likely pathogenic (P/LP) variants in

Indexed as

Allelic ImbalanceBRCA1 ProteinBRCA2 ProteinLoss of HeterozygosityNeoplasmsAdultAgedFemaleGenomic InstabilityHumansMaleMiddle AgedMutationRetrospective StudiesBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanBRCA1BRCA2genomic scarhomologous recombination deficiencyLOHLSTTAI

Identifiers

PMID42884094

DOI10.3390/ijms27198851

PMCPMC13664783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.