Evidence map›Paper›PMID 42884092›Full record

ArticleInternational journal of molecular sciences2026

Downregulation of GJA1-Derived circ_753 and circ_755 Differentially Modulates miR-182-5p Expression and Breast Cancer-Associated Phenotypes.

Nour Maatouk, Joséphine Briand, Jana Ismael, Serena Andraos, Abdallah Kurdi, Sophie Lelièvre, Rihab Nasr, Rabih Talhouk

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nour MaatoukDepartment of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut 1107 2020, Lebanon.
Joséphine BriandInstitut de Cancérologie de l'Ouest, 49055 Angers, France.
Jana IsmaelDepartment of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut 1107 2020, Lebanon.
Serena AndraosDepartment of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut 1107 2020, Lebanon.ORCID 0009-0007-1763-712X
Abdallah KurdiDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon.ORCID 0000-0002-8321-4025
Sophie LelièvreInstitut de Cancérologie de l'Ouest, 49055 Angers, France.
Rihab NasrDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon.ORCID 0000-0003-1166-4999
Rabih TalhoukDepartment of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut 1107 2020, Lebanon.ORCID 0000-0002-1544-1736

Funding

American University of Beirut - University Research Board (URB) 26748American University of Beirut - University Research Board (URB) 27611French Embassy in Lebanon - Safar
6 · The paper itself

Abstract

CircRNAs are key regulators of gene expression. The functional roles of exonic versus exon-intron circRNAs in early breast cancer remain unclear. Connexin-43 (

Indexed as

Breast NeoplasmsConnexin 43Down-RegulationGene Expression Regulation, NeoplasticMicroRNAsRNA, CircularCell Line, TumorFemaleHumansPhenotypeRNA, Competitive EndogenousConnexin 43GJA1 protein, humanMicroRNAsMIR182, humanRNA, CircularRNA, Competitive Endogenousbreast epithelial cellscircular RNA (circRNA)early breast cancer initiationextracellular vesicles (EVs)GJA1 (Connexin 43)microRNA (miRNA)three-dimensional (3D) culture

Identifiers

PMID42884092
PMCPMC13664854

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.