ArticleInternational journal of molecular sciences2026
Cynaroside Attenuates Ethinylestradiol-Induced Cholestatic Liver Injury by Modulating the FXR/BSEP/CYP7A1/SHP Axis.
Amany M Hamed, Doha M Al-Nouri, Nadia S Mahrous, Asmaa Sabry Bassit, Azza M A Abouelella, Asmaa Hassan, Gehad S Mokhtar, Ghada M Ahmad, Ahmed S Osman, Ahmed R H Ahmed and 7 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
17 authors.
Doha M Al-NouriDepartment of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 11495, Saudi Arabia.ORCID 0000-0002-1230-1471 Nadia S MahrousDepartment of Zoology, Faculty of Science, South Valley University, Qena 83523, Egypt.
Asmaa Sabry BassitAnatomy & Embryology Department, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.
Azza M A AbouelellaDepartment of Clinical Pharmacology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.
Asmaa HassanDepartment of Physiology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.
Gehad S MokhtarDepartment of Molecular Biology, Faculty of Applied Biotechnology, Merit University, Sohag 82755, Egypt.
Ghada M AhmadDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Canal El Mahmoudia Street, Beside Green Plaza Complex, Alexandria 21648, Egypt.ORCID 0000-0002-6824-5683 Ahmed S OsmanDepartment of Biochemistry, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt.
Aya A E MahgoobTechnology of Medical Laboratory Department, Higher Technology Institute of Applied Health Sciences, Badr Academy for Technology and Sciences, Badr City 11829, Egypt.
Shymaa A ThabetCentral Research Center, Faculty of Medicine, Sohag University, Sohag 82524, Egypt.
Hany M R Abdel-LatifDepartment of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria 26571, Egypt.ORCID 0000-0001-8761-1493 Ghalia ShamlanDepartment of Food and Nutrition Sciences, College of Food and Agriculture Sciences, King Saud University, Riyadh 11495, Saudi Arabia.ORCID 0000-0002-3095-3430 Haifeng ZhaoSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.ORCID 0000-0001-6009-3526 Ammar Al-FargaDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-0233-5539 Safaa S SolimanDepartment of Zoology, Faculty of Science, Minia University, Minia 61519, Egypt.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Cholestatic liver diseases are characterized by disrupted bile acid homeostasis, oxidative stress, and inflammation, ultimately leading to progressive hepatic injury. Although ursodeoxycholic acid (UDCA) remains the standard pharmacological therapy, its therapeutic efficacy is limited in several cholestatic conditions. This study investigated the hepatoprotective effects of cynaroside (CYN), a naturally occurring flavonoid glycoside, against ethinylestradiol (EE)-induced cholestatic liver injury and explored its underlying molecular mechanisms. Female Wistar rats were randomly allocated into four groups (
Indexed as
Chemical and Drug Induced Liver InjuryCholestasisCholesterol 7-alpha-HydroxylaseEthinyl EstradiolLuteolinReceptors, Cytoplasmic and NuclearAnimalsATP Binding Cassette Transporter, Subfamily B, Member 11FemaleLiverMolecular Docking SimulationOxidative StressRatsRats, WistarReceptor, Farnesoid X-ActivatedSignal TransductionAbcb11 protein, ratATP Binding Cassette Transporter, Subfamily B, Member 11Cholesterol 7-alpha-HydroxylaseCYP7A1 protein, ratEthinyl EstradiolLuteolinnuclear receptor subfamily 0, group B, member 2Receptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearcholestasiscynarosideethinylestradiolFXRhepatoprotectionNF-κBNrf2
Identifiers
PMID42884083
PMCPMC13665009
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