Evidence map›Paper›PMID 42884068›Full record

ArticleInternational journal of molecular sciences2026

Phosphatidic Acid Vesicles Convert the Prion Protein into β-Sheet Fibrils with a Thermostable Structure but Temperature-Sensitive Packing.

Cyntia Alves, Gabriela Assis-de-Lemos, Michel W Jaworek, Guilherme A P de Oliveira, Roland Winter, Jerson Lima Silva, Tuane C R G Vieira

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cyntia AlvesPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.ORCID 0009-0001-1904-2556
Gabriela Assis-de-LemosPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.ORCID 0000-0002-2804-3163
Michel W JaworekPhysical Chemistry I-Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany.
Guilherme A P de OliveiraPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.ORCID 0000-0002-0063-5888
Roland WinterPhysical Chemistry I-Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany.ORCID 0000-0002-3512-6928
Jerson Lima SilvaPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.ORCID 0000-0001-9523-9441
Tuane C R G VieiraPrograma de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, Brazil.ORCID 0000-0002-3574-5411

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 408046/2021- 0Conselho Nacional de Desenvolvimento Científico e Tecnológico 408046/2021-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 408340/2024-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 409103/2023-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 465395/2014-7Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.325/2021Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/203.170/2017Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/204.253/2024German Research Foundation 90677874-RESOLV
6 · The paper itself

Abstract

Biomolecular cofactors, including nucleic acids and lipids, promote conversion of the cellular prion protein (PrP

Indexed as

Phosphatidic AcidsPrion ProteinsAnimalsMiceProtein AggregatesProtein Conformation, beta-StrandProtein StabilityTemperaturePhosphatidic AcidsPrion ProteinsProtein Aggregatesaggregationfibrilizationlipid vesiclesphosphatidic acidprion protein

Identifiers

PMID42884068
PMCPMC13665344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.