ArticleInternational journal of molecular sciences2026
Minor Myeloid Leukemic Populations in Pediatric Acute Lymphoblastic Leukemia: A Potentially Underrecognized Mixed-Phenotype Tumor?
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
In "bilineal" mixed-phenotype acute leukemia (MPAL), the proportions of lymphoid and myeloid leukemic cells may differ substantially. A myeloid component may constitute <10% of bone marrow (BM) cells and show subtle immunophenotypic abnormalities detectable by multicolor flow cytometry (MFC). The significance of minor myeloid leukemic populations in otherwise acute lymphoblastic leukemia (ALL), including their association with lineage switch, remains uncertain. We retrospectively reviewed diagnostic MFC data from 5094 children with B-cell precursor or T-cell ALL. An additional minor myeloid leukemic population (<10% of BM) was identified in 92 ALL cases (1.8%), with a median of 3.0% of BM cells (0.2-9.2%). The frequency of ALL cases harboring a minor myeloid leukemic population was comparable to that of overt "bilineal" MPAL (with both populations ≥ 10% of BM cells), diagnosed during the same period. The myeloid populations expressed CD33, CD64, CD14, lysozyme, and markers shared with the dominant lymphoblastic population (CD19/CD7, CD34, CD117). Common genetic findings were high hyperdiploidy (
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