Evidence map›Paper›PMID 42884042›Full record

ArticleInternational journal of molecular sciences2026

Transcriptomic Profiling of Adherent Cells Isolated from Wedged Pulmonary Arterial Blood of Patients with Pulmonary Arterial Hypertension Reveals a Predominantly Myeloid Rather than Endothelial Phenotype.

Nadezhda Boyarskaya, Polina Kuchur, Pavel Docshin, Olga Skortsanu, Daria Smirnova, Natalia Goncharova, Elizaveta Korobchenko, Kirill Lapshin, Olga Moiseeva, Anna Malashicheva

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nadezhda BoyarskayaAlmazov National Medical Research Centre, 2 Akkuratova St., 197341 Saint Petersburg, Russia.ORCID 0000-0002-6402-770X
Polina KuchurInstitute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 Saint Petersburg, Russia.ORCID 0000-0002-9415-577X
Pavel DocshinAlmazov National Medical Research Centre, 2 Akkuratova St., 197341 Saint Petersburg, Russia.
Olga SkortsanuAlmazov National Medical Research Centre, 2 Akkuratova St., 197341 Saint Petersburg, Russia.ORCID 0009-0005-5388-8474
Daria SmirnovaInstitute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 Saint Petersburg, Russia.
Natalia GoncharovaAlmazov National Medical Research Centre, 2 Akkuratova St., 197341 Saint Petersburg, Russia.
Elizaveta KorobchenkoAlmazov National Medical Research Centre, 2 Akkuratova St., 197341 Saint Petersburg, Russia.
Kirill LapshinAlmazov National Medical Research Centre, 2 Akkuratova St., 197341 Saint Petersburg, Russia.
Olga MoiseevaAlmazov National Medical Research Centre, 2 Akkuratova St., 197341 Saint Petersburg, Russia.
Anna MalashichevaInstitute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 Saint Petersburg, Russia.ORCID 0000-0002-0820-2913

Funding

Russian Science Foundation 26-15-00311
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling and immune dysregulation. Myeloid angiogenic cells (MACs) are blood-derived mononuclear cells that acquire endothelial-like features at sites of vascular injury, but their transcriptomic phenotype in the pulmonary vascular compartment is poorly characterized. We isolated adherent cells from blood aspirated from the wedged pulmonary artery of four patients with severe PAH during right heart catheterization. The cells were vWF-positive and ACTA2-negative by immunocytochemistry and co-expressed canonical endothelial (

Indexed as

Endothelial CellsGene Expression ProfilingMyeloid CellsPulmonary Arterial HypertensionPulmonary ArteryTranscriptomeCells, CulturedCytokinesFemaleHumansMaleMiddle AgedPhenotypeCytokinescirculating endothelial cellsmatrix metalloproteinasesmonocyte-derived cellsmyeloid angiogenic cellspulmonary arterial hypertensionright heart catheterizationtranscriptomicsvascular inflammation

Identifiers

PMID42884042
PMCPMC13665573

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.