ArticleInternational journal of molecular sciences2026
Evolutionary Epigenetic Analysis of Oxidative Balance Score-Associated DNA Methylation Sites Across Mammals.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxidative Balance Score (OBS) summarizes diet- and lifestyle-related exposures relevant to redox homeostasis, but the evolutionary behavior of OBS-associated epigenetic markers remains unclear. In this study, we conducted a covariate-adjusted epigenome-wide association study (EWAS) in Korean Genome and Epidemiology Study (KoGES) cohorts, adjusting for OBS and cell-type proportions. We identified 26 robust OBS-associated CpG sites. We then mapped these loci to the Mammalian Methylation Consortium dataset (GSE223748) and examined age-related methylation dynamics across nine mammalian species, using chronological age as a proxy for cumulative oxidative burden. Cross-species analyses showed that human correlation patterns were only partially preserved, with greater concordance observed in primates than in several non-primate species. Furthermore, 1000-iteration bootstrap resampling and null-model sensitivity analyses (Robinson-Foulds distance) demonstrated that the interspecies clustering topology of these 26 CpGs is statistically robust and distinct from random genomic noise. These findings suggest partial evolutionary preservation of age-related methylation behavior at human OBS-associated loci, providing a comparative framework for redox-related epigenetic dynamics.
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