Construction of Adverse Outcome Pathway (AOP) for Triphenyl Phosphate (TPHP)-Induced Autism Spectrum Disorder (ASD) and Risk Identification of Neurodevelopmental Toxicity of Aryl Organophosphorus Flame Retardants (OPFRs) Based on Multidimensional Bioinformatic Data.

Yonghang Li, Kaidong Wang, Ai Qi, Qi Liu, Ge Shi, Min Huang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yonghang LiSchool of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan 750001, China.

Kaidong WangSchool of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan 750001, China.

Ai QiSchool of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan 750001, China.

Qi LiuSchool of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan 750001, China.

Ge ShiSchool of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan 750001, China.

Min HuangSchool of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan 750001, China.

Funding

The Key R&D Plan of Ningxia Hui Autonomous Region 2022BEG02027

6 · The paper itself

Abstract

Triphenyl phosphate (TPHP) is a widely used plasticizer and organophosphate flame retardant extensively applied in various industrial and consumer products. Due to its pervasive environmental exposure and detection in human samples such as amniotic fluid and breast milk, TPHP has become a pollutant of significant concern in recent years for its potential neurodevelopmental impacts on humans. This study employed a multimethod approach integrating network toxicology, transcriptomics, in silico gene knockout, molecular docking, and molecular dynamic simulations to investigate TPHP's potential toxic role in autism spectrum disorder (ASD). An adverse outcome pathway (AOP) was constructed, revealing that TPHP exposure may induce and exacerbate ASD by downregulating

Indexed as

Adverse Outcome PathwaysAutism Spectrum DisorderComputational BiologyFlame RetardantsOrganophosphatesOrganophosphorus CompoundsGlutamate DecarboxylaseHumansMolecular Docking SimulationMolecular Dynamics SimulationNeurodevelopmentFlame RetardantsGlutamate Decarboxylaseglutamate decarboxylase 1OrganophosphatesOrganophosphorus Compoundstriphenyl phosphateadverse outcome pathwayautism spectrum disordersimulated gene knockouttranscriptomicstriphenyl phosphate

Identifiers

PMID42884012

DOI10.3390/ijms27198769

PMCPMC13664942

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.