Early Hippocampal Stress Responses to Short-Term Cigarette Smoke Exposure in Mice.

Rubina Marzagalli, Ng Min Zhen, Christabella Winata, Yik Lung Chan, Venkata Sita Rama Raju Allam, Hui Chen, Brian Gregory George Oliver, Alessandro Castorina

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rubina MarzagalliLaboratory of Cellular and Molecular Neuroscience, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.

Ng Min ZhenLaboratory of Cellular and Molecular Neuroscience, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.

Christabella WinataLaboratory of Cellular and Molecular Neuroscience, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.

Yik Lung ChanSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.

Venkata Sita Rama Raju AllamSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.

Hui ChenSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID 0000-0001-6883-3752

Brian Gregory George OliverSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID 0000-0002-7122-9262

Alessandro CastorinaLaboratory of Cellular and Molecular Neuroscience, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.ORCID 0000-0001-7037-759X

Funding

University of Technology Sydney n/a

6 · The paper itself

Abstract

Cigarette smoke (CS) is a major environmental toxicant associated with cognitive impairment and neurodegenerative disease, yet the earliest hippocampal responses to short-term exposure remain poorly understood. Here, we investigated the effects of short-term CS exposure on hippocampal neuropeptide signalling, endoplasmic reticulum (ER) stress, mitochondrial homeostasis, neuroplasticity and astroglial activation. Mice were exposed to the equivalent of 0, 2, 4 or 6 cigarettes per exposure session, twice daily for four consecutive days, using a whole-body exposure paradigm. Hippocampal tissue was analysed by reverse transcription quantitative PCR, ELISA, immunofluorescence and histology. Short-term CS exposure disrupted hippocampal PACAP/VIP signalling, characterised by reduced

Indexed as

Endoplasmic Reticulum StressHippocampusSmokeAnimalsAstrocytesMaleMiceMice, Inbred C57BLMitochondriaSignal TransductionSmokecigarette smokeendoplasmic reticulum stresshippocampusmitochondrial dynamicsneuroinflammationneurotoxicityoxidative stress

Identifiers

PMID42884003

DOI10.3390/ijms27198760

PMCPMC13664968

What OpenQuestion holds

Textmetadata

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None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.