Evidence map›Paper›PMID 42884002›Full record

ArticleInternational journal of molecular sciences2026

Pan-Fibrotic Gene Expression Signature in Major Chronic Diseases by Integrative Bulk and Single-Cell Transcriptomic Analyses.

Mayra Alejandra Jaimes-Campos, Rafael Stroggilos, Joost P Schanstra, Antonia Vlahou, Manon Brunet, Jean-Christophe Jonas, Mohammed Bensellam, Harald Mischak, Agnieszka Latosinska

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mayra Alejandra Jaimes-CamposDepartment of Biomarker Research, Mosaiques Diagnostics GmbH, D-30659 Hannover, Germany.ORCID 0000-0003-4202-7810
Rafael StroggilosSystems Biology Center, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.ORCID 0000-0003-4068-9167
Joost P SchanstraInstitut National de la Santé et de la Recherche Médicale (INSERM), Institute of Metabolic and Cardiovascular Diseases, 31432 Toulouse, France.
Antonia VlahouSystems Biology Center, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.ORCID 0000-0003-3284-5713
Manon BrunetInstitut National de la Santé et de la Recherche Médicale (INSERM), Institute of Metabolic and Cardiovascular Diseases, 31432 Toulouse, France.
Jean-Christophe JonasPôle d'Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, B-1200 Brussels, Belgium.ORCID 0000-0001-9882-5438
Mohammed BensellamPôle d'Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, B-1200 Brussels, Belgium.ORCID 0000-0002-1641-1694
Harald MischakDepartment of Biomarker Research, Mosaiques Diagnostics GmbH, D-30659 Hannover, Germany.ORCID 0000-0003-0323-0306
Agnieszka LatosinskaDepartment of Biomarker Research, Mosaiques Diagnostics GmbH, D-30659 Hannover, Germany.ORCID 0000-0001-8917-2412

Funding

European Union's Horizon Europe Marie Skłodowska-Curie Actions 101072828PERMEDIK COST Action-European Cooperation in Science and Technology CA21165
6 · The paper itself

Abstract

Fibrosis is a shared feature of chronic liver, kidney and heart disease, yet no molecular signature captures the mechanisms common to these organs. We integrated human microarray, bulk and single-nucleus RNA sequencing (snRNA-seq) data across 2022 unique tissue samples to identify a conserved pan-fibrotic signature. The pan-fibrotic signature was defined in a microarray discovery cohort (

Indexed as

FibrosisGene Expression ProfilingLiver CirrhosisTranscriptomeChronic DiseaseHumansLiverSingle-Cell AnalysisSingle-Cell Gene Expression Analysisbiomarkerschronic diseasesfibrosissingle celltranscriptomics

Identifiers

PMID42884002
PMCPMC13665512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.