Evidence map›Paper›PMID 42883978›Full record

ArticleInternational journal of molecular sciences2026

In Vitro Antigiardial Activity and In Silico Target Exploration of Quassinoids Isolated from

Ulises Murrieta-Dionicio, Fernando Calzada, Elizabeth Barbosa, Miguel Valdes, Jesica Ramirez-Santos, Benito Reyes-Trejo, Holber Zuleta-Prada, Lino Reyes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ulises Murrieta-DionicioLaboratorio de Productos Naturales, Área de Química, Departamento de Preparatoria Agrícola, Universidad Autónoma Chapingo, Chapingo 56230, Mexico.ORCID 0000-0003-1041-4090
Fernando CalzadaUnidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, 2° Piso CORSE Centro Médico Nacional Siglo XXI, IMSS, Ciudad de Mexico 06720, Mexico.ORCID 0000-0003-1851-5988
Elizabeth BarbosaEscuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de Mexico 07738, Mexico.ORCID 0000-0002-7111-7922
Miguel ValdesUnidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, 2° Piso CORSE Centro Médico Nacional Siglo XXI, IMSS, Ciudad de Mexico 06720, Mexico.ORCID 0000-0001-7401-303X
Jesica Ramirez-SantosUnidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, 2° Piso CORSE Centro Médico Nacional Siglo XXI, IMSS, Ciudad de Mexico 06720, Mexico.ORCID 0000-0002-2673-4366
Benito Reyes-TrejoLaboratorio de Productos Naturales, Área de Química, Departamento de Preparatoria Agrícola, Universidad Autónoma Chapingo, Chapingo 56230, Mexico.ORCID 0000-0001-9330-2646
Holber Zuleta-PradaLaboratorio de Productos Naturales, Área de Química, Departamento de Preparatoria Agrícola, Universidad Autónoma Chapingo, Chapingo 56230, Mexico.ORCID 0000-0001-6372-2885
Lino ReyesDepartamento de Química Orgánica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Delegación Coyoacán 04510, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Giardiasis is a parasitic disease for which there is a growing need to develop new therapeutic alternatives due to the adverse effects associated with first-line treatments such as metronidazole and the increasing emergence of resistant strains. In this study, the in vitro antigiardial activity of three quassinoids, chaparrin (

Indexed as

Antiprotozoal AgentsGiardia lambliaPlant ExtractsQuassinsAnimalsComputer SimulationMolecular Docking SimulationAntiprotozoal AgentsPlant ExtractsQuassinsantigiardial activityCastela tortuosachaparrinoneGiardia lambliain vitro and in silico studiesquassinoids

Identifiers

PMID42883978
PMCPMC13665569

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.