In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Luis H Pagán-RiveraDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0009-0002-7939-6812 Filipa Godoy-VitorinoDepartment of Microbiology and Immunology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0003-1880-0498 Samuel E Ocasio-RiveraDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0001-6580-0242 Maria E Santiago-GascotDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
Viviana GonzálezDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
José M SantiagoDepartment of Natural Sciences, University of Puerto Rico Carolina Campus, Carolina, PR 00984, USA.ORCID 0000-0002-0615-5033 Aranza Torrado-TapiasNational Institutes of Health, National Human Genome Research Institute, Bethesda, MD 20892, USA.ORCID 0009-0001-3365-1753 Jennifer M Colón-MercadoDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
Carolina García-GuayDepartment of Psychology, University of Puerto Rico Rio Piedras Campus, San Juan, PR 00926, USA.ORCID 0009-0004-1066-4537 Jorge D MirandaDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
Funding
SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Humberto Guillermo Ortiz-Zuazaga · 2012 to 2026
$52.9MUpstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Emma Fernandez-Repollet · 2017 to 2026
$35.8MThe contribution of gut microbiome composition to natural variation in sleep and aggression across populations in the blind Mexican cavefishP20GM156713 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Yancy Ferrer-Acosta · 2025 to 2026
$6.8MResearch Projects CoreP30GM149367 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Walter I Silva · 2023 to 2026
$5.6MNeuroscience Research Opportunities to Increase Diversity (NeuroID)R25NS080687 · NINDS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI GARCIA-ARRARAS, JOSE E, MALDONADO-VLAAR, CARMEN SARA · 2012 to 2024
$5.3MUPR MSC Transdisciplinary Basic Biomedical Sciences Training ProgramT32GM164035 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jennifer Luz Barreto Estrada, CARMEN LYDIA CADILLA · 2026 to 2026
$1.6MEffects of Tamoxifen in skeletal muscle recovery after spinal cord injury and mechanisms activated by the drugSC1GM144032 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI MIRANDA, JORGE DAVID · 2022 to 2025
$1.5MNIGMS NIH HHS P20 GM103475NIGMS NIH HHS P20 GM156713NIGMS NIH HHS P30 GM149367NIGMS NIH HHS SC1 GM144032NIGMS NIH HHS T32 GM164035NIH HHS 4SC1GM144032-04NIMHD NIH HHS U54 MD007600NINDS NIH HHS R25 NS080687
6 · The paper itselfAbstract
Spinal cord injury (SCI) triggers complex secondary injury cascades that limit neurological recovery. Tamoxifen (TAM), a selective estrogen receptor modulator, exerts neuroprotective effects in experimental SCI, although its underlying mechanisms remain unknown. Given the emerging role of gut microbiota dysregulation in SCI, we investigated whether TAM-associated recovery is accompanied by alterations in gut microbial composition and predicted function. We conducted a longitudinal, sex-inclusive analysis of 61 Sprague-Dawley rats of both sexes assigned to naïve (NAÏVE), sham-placebo (SHAM PLB), sham-TAM (SHAM TAM), injured-placebo (INJ PLB), or injured-TAM (INJ TAM) groups. Injured animals received a moderate T10 contusion followed by a 21-day TAM (0.71 mg/day) or placebo pellet, and fecal samples were collected at 0, 7, 14, 21, and 28 days post-injury. Fecal samples were analyzed by 16S rRNA gene sequencing. Results showed that TAM induced sustained shifts in microbial community composition, with treatment-associated divergence emerging at 14 days post-injury (DPI) in females and 21 DPI in males.
Indexed as
BifidobacteriumGastrointestinal MicrobiomeSpinal Cord InjuriesTamoxifenAnimalsFecesFemaleMaleRatsRats, Sprague-DawleyRNA, Ribosomal, 16SRNA, Ribosomal, 16STamoxifenanti-inflammatorygut–brain axismicrobiomeneuroprotectiveselective estrogen receptor modulatortrauma
Identifiers
PMID42883973
PMCPMC13664996
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