Evidence map›Paper›PMID 42883957›Full record

ArticleInternational journal of molecular sciences2026

Adjuvant Effect of Meldrum's Acid Derivatives on Antibiotic Activity Against Multidrug-Resistant Bacteria.

Isaac Moura Araújo, Ewerton Yago de Sousa Rodrigues, Daniel Sampaio Alves, Clara Mariana Gonçalves Lima, Sheila Alves Gonçalves, Cícera Georgia Brito Milfont, Alisson Justino Alves da Silva, João Arthur de Oliveira Borges, Cícera Datiane de Morais Oliveira-Tintino, Samara Alves Brito and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Isaac Moura AraújoDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.ORCID 0000-0002-6544-0141
Ewerton Yago de Sousa RodriguesDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
Daniel Sampaio AlvesDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
Clara Mariana Gonçalves LimaDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.ORCID 0000-0002-3150-9139
Sheila Alves GonçalvesDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
Cícera Georgia Brito MilfontDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
Alisson Justino Alves da SilvaDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.ORCID 0009-0003-5897-2857
João Arthur de Oliveira BorgesDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
Cícera Datiane de Morais Oliveira-TintinoDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
Samara Alves BritoDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
José Thyálisson da Costa SilvaDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.ORCID 0009-0002-7522-2989
Francisco Assis Bezerra da CunhaDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.
Ricardo Andrade RebeloDepartment of Chemistry, Regional University of Blumenau, FURB, Blumenau 89030-903, Santa Catarina, Brazil.ORCID 0000-0003-1362-1837
Iêda Maria BegniniDepartment of Chemistry, Regional University of Blumenau, FURB, Blumenau 89030-903, Santa Catarina, Brazil.
Renata SalamoniDepartment of Chemistry, Regional University of Blumenau, FURB, Blumenau 89030-903, Santa Catarina, Brazil.ORCID 0009-0001-4939-5707
Luiz Everson da SilvaDepartment of Chemistry, Federal University of Paraná, UFPR, Curitiba 81531-970, Paraná, Brazil.ORCID 0000-0002-2332-3553
Nathalia Monteiro Lins FreireInstitute of Chemistry and Biotechnology, Federal University of Alagoas, UFAL, Maceió 57072-970, Alagoas, Brazil.ORCID 0009-0006-7079-1751
Renata Ferreira SantanaDepartment of Nutrition, Federal University of Tocantins, Palmas 77001-090, Tocantins, Brazil.
Thiago Mendonça de AquinoInstitute of Chemistry and Biotechnology, Federal University of Alagoas, UFAL, Maceió 57072-970, Alagoas, Brazil.
Saulo Relison TintinoDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.ORCID 0000-0002-7733-9331
Henrique Douglas Melo CoutinhoDepartment of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, Ceará, Brazil.ORCID 0000-0002-6634-4207

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 151037/2025-6
6 · The paper itself

Abstract

Antimicrobial resistance demands new strategies capable of restoring the effectiveness of conventional antibiotics. In this study, the antibacterial activity and adjuvant potential of five Meldrum's acid derivatives (MAD1-MAD5) against multidrug-resistant strains of

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialEscherichia coliStaphylococcus aureusAdenosine TriphosphateCell Membrane PermeabilityMicrobial Sensitivity TestsNorfloxacinAdenosine TriphosphateAnti-Bacterial AgentsNorfloxacinadjuvant antimicrobial activitybacterial ATPbacterial resistanceMeldrum’s acidmembrane permeability

Identifiers

PMID42883957
PMCPMC13665451

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.