Evidence map›Paper›PMID 42883944›Full record

ArticleInternational journal of molecular sciences2026

Stage-Specific Rewiring of PI3K-AKT Signaling During Serous Ovarian Cancer Progression: An Integrated Transcriptomic and Network Analysis.

Iman Jaafar Abdulrahman, Sana Ismael Ameen, Hossein Azizi, Thomas Skutella

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Iman Jaafar AbdulrahmanObstetrics and Gynecology Department, Akre Obstetrics and Gynecology Hospital, Duhok General Directorate of Health, Ministry of Health, Duhok 42001, Kurdistan Region, Iraq.
Sana Ismael AmeenDepartment of Gynecology and Obstetrics, Faculty of General Medicine, Koya University, Koya 44023, Kurdistan Region, Iraq.
Hossein AziziDepartment of Stem Cells and Cancer, College of Biotechnology, Amol University of Special Modern Technologies, Amol 49767, Iran.ORCID 0000-0001-8246-595X
Thomas SkutellaInstitute for Anatomy and Cell Biology, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany.ORCID 0000-0003-4813-1213

Funding

Heidelberg University 1404.12.03Koya University 16/243178 and 14/20/29388
6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSOC) exhibits substantial molecular heterogeneity during disease progression. We investigated stage-specific changes in PI3K-AKT-associated signaling programs from early tumorigenesis to metastatic disease. Two publicly available microarray datasets, GSE36668 (normal, borderline, and carcinoma;

Indexed as

Cystadenocarcinoma, SerousGene Regulatory NetworksOvarian NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTranscriptomeDisease ProgressionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansNeoplasm StagingProtein Interaction MapsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktcancer progressionGEO analysishigh-grade serous ovarian carcinomaPI3K–AKT signalingtranscriptomics

Identifiers

PMID42883944
PMCPMC13665355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.