Evidence map›Paper›PMID 42883940›Full record

ArticleInternational journal of molecular sciences2026

Deletion of α7 Nicotinic Acetylcholine Receptor in POMC Neurons Impairs Energy Balance and Leptin-Induced Anorexigenic Response in Male Mice.

Wenicios Ferreira Chaves, Suleyma de Oliveira Costa, Caroline Lobo Costa, Priscilla Karla Fernandes Lopes, Iracema Monteiro da Silva, Ísis de Cássia Alves Martins, Marciane Milanski, Letícia Martins Ignácio de Souza, Adriana Souza Torsoni, Raquel da Silva Aragão and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenicios Ferreira ChavesLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.ORCID 0000-0002-6582-417X
Suleyma de Oliveira CostaLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.
Caroline Lobo CostaLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.ORCID 0000-0002-2792-5551
Priscilla Karla Fernandes LopesLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.
Iracema Monteiro da SilvaLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.
Ísis de Cássia Alves MartinsLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.ORCID 0000-0002-7446-3521
Marciane MilanskiLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.ORCID 0000-0002-6322-5368
Letícia Martins Ignácio de SouzaLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.
Adriana Souza TorsoniLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.
Raquel da Silva AragãoGraduate Program in Nutrition, Federal University of Pernambuco (UFPE), Recife 50670-901, Brazil.ORCID 0000-0003-0630-7030
Marcio Alberto TorsoniLaboratory of Metabolic Disorders, School of Applied Sciences, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, Brazil.ORCID 0000-0002-9663-5291

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/06661-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/11772-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/11144-5
6 · The paper itself

Abstract

Recent studies demonstrate that α7 nicotinic acetylcholine receptors (α7nAChR) in hypothalamic neurons, including pro-opiomelanocortin (POMC) neurons, modulate energy homeostasis. This study aimed to explore how the α7nAChR subunit in hypothalamic POMC neurons affects food intake and energy balance in mice. This study used site-specific knockout mice for α7nAChR in POMC neurons (Control: α7nAChR

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorEnergy MetabolismLeptinNeuronsPro-OpiomelanocortinAnimalsBenzamidesBody WeightBridged Bicyclo CompoundsEatingHomeostasisHypothalamusMaleMiceMice, Knockoutalpha7 Nicotinic Acetylcholine ReceptorBenzamidesBridged Bicyclo CompoundsLeptinPNU-282987Pro-Opiomelanocortincholinergic receptorenergy balanceglycemic homeostasishypothalamussatiety

Identifiers

PMID42883940
PMCPMC13664977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.