Evidence map›Paper›PMID 42883938›Full record

ArticleInternational journal of molecular sciences2026

Effect of Clodronate on the Pathogenesis in a Mouse Model of Lysosomal Acid Lipase Deficiency.

Ryuichi Mashima, Shuji Takada, Kei Murayama, Takashi Hamazaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryuichi MashimaDepartment of Clinical Laboratory Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
Shuji TakadaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.ORCID 0000-0002-9406-4683
Kei MurayamaDiagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8421, Japan.
Takashi HamazakiDepartment of Pediatrics, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.

Funding

Japan Society for the Promotion of Science 22K07927Japan Society for the Promotion of Science 25K11117Sanofi LSD grant FY2022
6 · The paper itself

Abstract

Lysosomal acid lipase deficiency (LAL-D, OMIM #309900), caused by mutations of the

Indexed as

Clodronic AcidWolman DiseaseAnimalsCholesterolDisease Models, AnimalLiposomesLiverMaleMiceOrgan SizeSpleenSterol EsteraseTriglyceridesCholesterolClodronic AcidLiposomesSterol EsteraseTriglyceridesclodronateLysosomal acid lipase deficiencymacrophage

Identifiers

PMID42883938
PMCPMC13665179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.