ArticleInternational journal of molecular sciences2026
Energy Metabolic Reprogramming Characterized by Succinate Accumulation Aggravates Necrotizing Enterocolitis.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Necrotizing enterocolitis (NEC) is a severe inflammatory intestinal disorder of preterm infants associated with substantial morbidity and mortality. This study investigated energy metabolic alterations in NEC and the contribution of succinate to disease progression. Fecal energy metabolites were quantified by high-performance liquid chromatography-mass spectrometry in preterm infants and neonatal mice. Neonatal C57BL/6 mice were assigned to the Control, NEC, NEC+dimethyl malonate (DMM), NEC+succinate (Suc), and NEC+DMM+Suc groups. Ileal tissues were analyzed by metabolomics, transcriptomics, histopathology, immunofluorescence, flow cytometry, Western blotting, reverse transcription quantitative PCR, and succinate dehydrogenase (SDH) activity assays. Both human neonates and neonatal mice with NEC exhibited metabolic reprogramming characterized by prominent succinate accumulation. Exogenous succinate further altered intestinal metabolism, reduced survival, aggravated weight loss and intestinal injury, decreased tight junction protein expression and lamina propria CD4
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