ArticleInternational journal of molecular sciences2026
A Retrospective Analysis of the Association Between Prediabetes and Biomarkers of Intestinal Permeability in Patients with Prediabetes from Durban, South Africa.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insufficient insulin production and diminished insulin receptor sensitivity. Prediabetes, which often precedes T2DM, involves elevated blood glucose levels that do not yet meet T2DM diagnostic criteria. Research has shown that complications linked to T2DM often begin during this prediabetic phase. In this study, we examined changes in intestinal barrier integrity during prediabetes by measuring biomarkers associated with intestinal permeability. With ethical approval, samples were collected from King Edward Hospital and Albert Luthuli Central Hospital in Durban and categorized into type 2 diabetes (T2D), prediabetes (PD), and non-prediabetes (NPD) groups. Blood levels of neutrophils and HbA1c were measured and analyzed, followed by serum zonulin and plasma levels of markers, including IFABP, sCD14, TNF-α, IL-6, glucose, insulin, and pancreatic lipase, which were measured and analyzed. The results showed significantly higher levels of these markers in the PD group compared to the NPD group, with further elevations in the T2D group. These findings align with existing research suggesting an association between increased intestinal permeability and the development of prediabetes. Altogether, these results indicate that prediabetes is a transitional phase marked by metabolic and intestinal permeability changes, though less severe than in T2DM. This underscores the need for additional research to cover a wider range of metabolic health, oxidative stress, inflammation, and vascular function markers, as such comprehensive assessments could provide deeper insight into underlying physiological processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.