ArticleInternational journal of molecular sciences2026
Integrated Multi-Omics Reveals Disruption of Lipid-Steroid Regulatory Axis Underlying Chronic Heat Stress-Induced Ovarian Dysfunction in Mice.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Heat stress is an escalating environmental challenge that adversely affects mammalian reproductive physiology, yet the integrated molecular mechanisms through which ovarian tissue responds to sustained heat stress remain incompletely understood. This study investigated the effects of chronic heat stress on mouse ovarian tissue using an integrated multi-omics approach. Female C57BL/6 mice were exposed to heat stress at 42 °C for 20 min daily over 30 days. Whole ovarian tissues were subsequently analyzed using RNA sequencing, DIA-based proteomics, untargeted metabolomics, histological examination, and RT-qPCR validation. Histological analysis showed a significant reduction in secondary follicle profiles in heat-stressed mice, whereas primary and antral follicle profiles showed inter-animal variability and did not differ significantly between groups. Transcriptomic and proteomic analyses identified altered expression of lipid metabolism- and steroidogenesis-related molecules, including
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