Evidence map›Paper›PMID 42883911›Full record

ArticleInternational journal of molecular sciences2026

Therapeutic Administration of

Itzel Rojas-Sánchez, Eladio Cortes-Flores, Nohemi Camacho-Concha, Jorge Luis Almazán, Leticia Ramírez-Lugo, Esther Crivelli-Galindo, Cristina E Ramirez-Serrano, Gustavo Pedraza-Alva, Leonor Pérez-Martínez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Itzel Rojas-SánchezLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.
Eladio Cortes-FloresLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.
Nohemi Camacho-ConchaLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.
Jorge Luis AlmazánLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.ORCID 0009-0000-3504-7966
Leticia Ramírez-LugoDepartamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, AP 70-253, Ciudad de México 04510, Ciudad de México, Mexico.
Esther Crivelli-GalindoLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.ORCID 0009-0004-1963-5935
Cristina E Ramirez-SerranoLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.
Gustavo Pedraza-AlvaLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.ORCID 0000-0002-6978-1218
Leonor Pérez-MartínezLaboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Morelos, Mexico.ORCID 0000-0003-4163-1653

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías CBF2023-2024-878Consejo Nacional de Humanidades, Ciencias y Tecnologías IFC 2016-2282Dirección General de Asuntos del Personal Académico (DGAPA), Universidad Nacional Autónoma de México (UNAM) PAPIIT IN216922Dirección General de Asuntos del Personal Académico (DGAPA), Universidad Nacional Autónoma de México (UNAM) PAPIIT IN217822Dirección General de Asuntos del Personal Académico (DGAPA), Universidad Nacional Autónoma de México (UNAM) PAPIIT IN222925
6 · The paper itself

Abstract

The remarkable increase in human life expectancy has been accompanied by a rising global incidence of neurodegenerative disorders, particularly Alzheimer's disease. This condition is characterized by progressive accumulation of soluble and insoluble amyloid-beta peptides, neuroinflammation, and synaptic dysfunction in the hippocampus, leading to impaired higher-order cognition. Epidemiological evidence indicates that women are disproportionately affected; however, female-specific pathology remains understudied. Here, we evaluated the therapeutic potential of a hydroalcoholic extract of

Indexed as

Alzheimer DiseaseCognitionMalvaPlant ExtractsAmyloid beta-PeptidesAnimalsDisease Models, AnimalFemaleGlial Fibrillary Acidic ProteinHippocampusLong-Term PotentiationMiceMice, TransgenicNeuronal PlasticityPhenotypeAmyloid beta-PeptidesGlial Fibrillary Acidic ProteinPlant ExtractsAlzheimer’s diseasefemale 5XFADlong-term potentiationMalva parvifloramemoryneuroinflammationreactive astrogliosisresilient phenotypesynaptic plasticitytherapeutic treatment

Identifiers

PMID42883911
PMCPMC13664929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.