ArticleInternational journal of molecular sciences2026
Y-Chromosomal Variation in Uyghurs from Kazakhstan Reveals High Paternal Diversity and Close Affinity with Xinjiang Uyghurs.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Y-chromosomal reference data from Uyghur communities outside China remain limited, although these populations are central to understanding paternal genetic structure in Central Asia. We analysed 596 reportedly unrelated Uyghur males from four regions of southeastern Kazakhstan using 27 Y-STR loci and 20 core Y-SNP markers, and compared the resulting haplotypes with Uyghur and neighbouring Central Asian populations from the Y-Chromosome Haplotype Reference Database. The dataset yielded 515 distinct haplotypes, high overall haplotype diversity (0.9993), and a low observed haplotype match probability (0.0023), providing a robust baseline for forensic applications. The paternal pool was highly heterogeneous, with major contributions from R1a (19.97%), J2 (17.45%), C2 (12.25%) and O2 (10.74%) lineages, alongside additional minor western, eastern and northern Eurasian components. Median-joining networks displayed complex, multi-branched topologies, while an exploratory comparison with a separate, previously published NGS dataset (
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